Mt2A cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mt2A
Entrez Gene ID	689415
Full Name	metallothionein 2A
Synonyms	Mt2
General protein information	Preferred Names metallothionein 2A Names metallothionein 2A
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001137564.1	NP_001131036.1	metallothionein 2A

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Mt1m	XP_002728963.1
Rattus norvegicus (Norway rat)	Mt2A	NP_001131036.1

Gene Ontology
Bibliography

Related articles in PubMed

Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats.
Grubi? Kezele T, Blagojevi? Zagorac G, Jakovac H, Domitrovi? R, Rado?evi?-Sta?i? B
Histology and histopathology32(2)137-151(2017 02)

Age-related changes of metallothionein 1/2 and metallothionein 3 expression in rat brain.
Scudiero R, Cigliano L, Verderame M
Comptes rendus biologies340(1)13-17(2017 Jan)

Long-Term Effects of Ketogenic Diet on Subsequent Seizure-Induced Brain Injury During Early Adulthood: Relationship of Seizure Thresholds to Zinc Transporter-Related Gene Expressions.
Tian T, Li LL, Zhang SQ, Ni H
Biological trace element research174(2)369-376(2016 Dec)

Melatonin relieves neuropathic allodynia through spinal MT2-enhanced PP2Ac and downstream HDAC4 shuttling-dependent epigenetic modification of hmgb1 transcription.
Lin TB, Hsieh MC, Lai CY, Cheng JK, Wang HH, Chau YP, Chen GD, Peng HY
Journal of pineal research60(3)263-76(2016 Apr)

Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System.
Siddiq MM, Hannila SS, Carmel JB, Bryson JB, Hou J, Nikulina E, Willis MR, Mellado W, Richman EL, Hilaire M, Hart RP, Filbin MT
The Journal of biological chemistry290(26)16343-56(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

acute attack of experimental autoimmune encephalomyelitis was followed by increased expression of metallothioneins in molecular and granular cell layer of hippocampus.
Title: Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats.

observe a huge increase in MT3 transcripts in both cortical and hippocampal areas, while the MT1/2 mRNA content increases slightly, returning to the levels measured in adolescent rats
Title: Age-related changes of metallothionein 1/2 and metallothionein 3 expression in rat brain.

The recurrent seizures plus normal diet group showed worse performances in neurological reflex tests and reduced latencies to myoclonic seizures induced by penicillin compared with the control, which was concomitant with altered expressions of ZnT-7, MT-1, MT-2, and ZIP7.
Title: Long-Term Effects of Ketogenic Diet on Subsequent Seizure-Induced Brain Injury During Early Adulthood: Relationship of Seizure Thresholds to Zinc Transporter-Related Gene Expressions.

Melatonin -exhibited anti-allodynia is mediated by MT2-enhanced PP2Ac expression that couples PP2Ac with HDAC4 to induce HDAC4 dephosphorylation and nuclear import, herein increases HDAC4 binding to the promoter of hmgb1 gene and upregulates HMGB1 expression in dorsal horn neurons.
Title: Melatonin relieves neuropathic allodynia through spinal MT2-enhanced PP2Ac and downstream HDAC4 shuttling-dependent epigenetic modification of hmgb1 transcription.

MT-I/II are required for the conditioning lesion effect and can promote axonal regeneration in the injured central nervous system.
Title: Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System.

The following Mt2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mt2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04229	NM_001137564.1 Latest version!	Rattus norvegicus metallothionein 2A (Mt2A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mt2A ( NM_001137564.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001131036.1 Rattus norvegicus metallothionein 2A (Mt2A), mRNA.

Price & Availability↑

CloneID	ORa04229
Clone ID Related Accession (Same CDS sequence)	NM_001137564.1
Accession Version	NM_001137564.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 186bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Rattus norvegicus(Norway rat)
Product	metallothionein 2A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC168768.1. On or before Nov 13, 2008 this sequence version replaced XM_001062488.1, XM_001070713.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC168768.1, FQ210821.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGGACCCCA ACTGCTCCTG TGCCACAGAT GGATCCTGCT CCTGCGCTGG CTCCTGCAAA 
TGCAAACAAT GCAAATGCAC CTCCTGCAAG AAAAGCTGCT GTTCCTGCTG CCCCGTGGGC 
TGTGCGAAGT GCTCCCAGGG CTGCATCTGC AAAGAGGCTT CGGACAAGTG CAGCTGCTGC 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001131036.1
CDS	63..248
Translation	MDPNCSCATDGSCSCAGSCKCKQCKCTSCKKSCCSCCPVGCAKCSQGCICKEASDKCSCCA

Target ORF information:

RefSeq Version	NM_001137564.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus metallothionein 2A (Mt2A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001137564.1

ORF Insert Sequence:

ATGGACCCCA ACTGCTCCTG TGCCACAGAT GGATCCTGCT CCTGCGCTGG CTCCTGCAAA 
TGCAAACAAT GCAAATGCAC CTCCTGCAAG AAAAGCTGCT GTTCCTGCTG CCCCGTGGGC 
TGTGCGAAGT GCTCCCAGGG CTGCATCTGC AAAGAGGCTT CGGACAAGTG CAGCTGCTGC 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats.
Histology and histopathology32(2)137-151(2017 02)
Grubi? Kezele T,Blagojevi? Zagorac G,Jakovac H,Domitrovi? R,Rado?evi?-Sta?i? B

Age-related changes of metallothionein 1/2 and metallothionein 3 expression in rat brain.
Comptes rendus biologies340(1)13-17(2017 Jan)
Scudiero R,Cigliano L,Verderame M

Long-Term Effects of Ketogenic Diet on Subsequent Seizure-Induced Brain Injury During Early Adulthood: Relationship of Seizure Thresholds to Zinc Transporter-Related Gene Expressions.
Biological trace element research174(2)369-376(2016 Dec)
Tian T,Li LL,Zhang SQ,Ni H

Melatonin relieves neuropathic allodynia through spinal MT2-enhanced PP2Ac and downstream HDAC4 shuttling-dependent epigenetic modification of hmgb1 transcription.
Journal of pineal research60(3)263-76(2016 Apr)
Lin TB,Hsieh MC,Lai CY,Cheng JK,Wang HH,Chau YP,Chen GD,Peng HY

Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System.
The Journal of biological chemistry290(26)16343-56(2015 Jun)
Siddiq MM,Hannila SS,Carmel JB,Bryson JB,Hou J,Nikulina E,Willis MR,Mellado W,Richman EL,Hilaire M,Hart RP,Filbin MT

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Mt2A cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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