Srebf1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Srebf1
Entrez Gene ID	78968
Full Name	sterol regulatory element binding transcription factor 1
Synonyms	ADD-1,ADD1,SREBP-1,SREBP-1c,Srebp1
General protein information	Preferred Names sterol regulatory element binding transcription factor 1 Names sterol regulatory element-binding protein 1 adipocyte determination- and differentiation-dependent factor 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q22
Summary	transcription factor; binds to the sterol regulatory element 1; regulates the transcription of genes important for sterol biosynthesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001276708.1	NP_001263637.1	sterol regulatory element-binding protein 1 isoform 2
NM_001276707.1	NP_001263636.1	sterol regulatory element-binding protein 1 isoform 1 precursor
XM_017597541.1	XP_017453030.1	sterol regulatory element-binding protein 1 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SREBF1	XP_003315641.1
Mus musculus (house mouse)	Srebf1	NP_035610.1
Rattus norvegicus (Norway rat)	Srebf1	NP_001263636.1
Danio rerio (zebrafish)	srebf1	NP_001098599.1
Drosophila melanogaster (fruit fly)	HLH106	NP_001262064.1
Homo sapiens (human)	SREBF1	NP_001005291.1
Canis lupus familiaris (dog)	SREBF1	NP_001184012.1
Gallus gallus (chicken)	SREBF1	NP_989457.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000076	XP_311076.5
	SREBF1	XP_001095392.1
Xenopus tropicalis (tropical clawed frog)	srebf1	XP_002935886.1
Bos taurus (cattle)	SREBF1	NP_001106773.1

Gene Ontology
Bibliography

Related articles in PubMed

Elevated sterol regulatory elementary binding protein 1 and GluA2 levels in the hippocampal nuclear fraction of Genetic Absence Epilepsy Rats from Strasbourg.
Sekar S, Omran E, Gopalakrishnan V, Howland JG, Snutch TP, Taghibiglou C
Epilepsy research1361-4(2017 Oct)

Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.
Tajima-Shirasaki N, Ishii KA, Takayama H, Shirasaki T, Iwama H, Chikamoto K, Saito Y, Iwasaki Y, Teraguchi A, Lan F, Kikuchi A, Takeshita Y, Murao K, Matsugo S, Kaneko S, Misu H, Takamura T
The Journal of biological chemistry292(26)10791-10800(2017 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A chromatin immunoprecipitation (ChIP) assay revealed that EPA decreases binding of SREBP-1c to the SELENOP promoter. Knockdown of Srebf1 resulted in a significant down-regulation of Selenop expression.
Title: Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.

PPAR-alpha inhibitor (Blueberry Juice and Probiotics) increased the level of SREBP-1c and PNPLA-3 and prevents nonalcoholic steatohepatitis progression by affecting SREBP-1c/PNPLA-3 pathway via PPAR-alpha.
Title: The Combination of Blueberry Juice and Probiotics Ameliorate Non-Alcoholic Steatohepatitis (NASH) by Affecting SREBP-1c/PNPLA-3 Pathway via PPAR-?.

The involvement of SREBP-1c in FASN promoter histone modification.
Title: Histone modifications in FASN modulated by sterol regulatory element-binding protein 1c and carbohydrate responsive-element binding protein under insulin stimulation are related to NAFLD.

a novel role for SREBP-1 as a cell surface retention factor for TbetaRI in mesangial cells, is reported.
Title: Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-? receptor I (T?RI) through exosomal secretion.

The present study indicates a requirement for C/EBPbeta in the insulin-mediated induction of SREBP-1c mRNA expression in rodent liver. Coupled with previous data showing that this induction requires LXRalpha, our data reported herein indicate a requirement for both transcription factors.
Title: Insulin induction of SREBP-1c in rodent liver requires LXR?-C/EBP? complex.

The following Srebf1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Srebf1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa57489	XM_017597541.1 Latest version!	Rattus norvegicus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
ORa12263	NM_001276707.1 Latest version!	Rattus norvegicus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00
ORa12273	NM_001276708.1 Latest version!	Rattus norvegicus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Srebf1 ( XM_017597541.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017453030.1 Rattus norvegicus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa57489
Clone ID Related Accession (Same CDS sequence)	XM_017597541.1
Accession Version	XM_017597541.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3183bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	sterol regulatory element-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACGAGC TACCCTTCGG TGAGGCGGCT CTGGAACAGG CACTGGCCGA GGTGTGCGAA 
ATGGACGCGG CGCTCTTGAC CGACATCGAA GACATGCTTC AGCTCATCAA CAACCAAGAC 
AGTGACTTCC CTGGCCTATT TGATGCCCCC TATGCTGGGG GTGAGACAGG AGACACAGGC 
CCCAGCAGCC CTGGTGCCAG CTCTCCTGAG AGCTTCTCTT CTCCTGCTTC TCTGGGCTCC 
TCTCTGGAAG CCTTCCTGGG AGGACCCAAG GTGACACCTG CACCCTTGTC CCCTCCACCA 
TCGGCACCCA CTGCTGTAAA GATGTACCCG TCCGTGCCCC CCTTCTCCCC TGGGCCTGGA 
ATCAAAGAGG AGCCAGTGCC ACTCACCATC CTGCAGCCCC CAGCACCACA GCCATCGCCA 
GGGACCCTGT TGCCTCCGAG CTTCCCTCCT CCACCTGTGC AGCTCAGCCC TGCTCCTGTG 
CTGGGGTACT CAAGCCTGCC TTCCGGCTTC TCAGGAACCC TTCCTGGGAA CACCCAGCAG 
ACGCCATCTA GCCTGCCACT GGGCTCCACG CCAGGAATCT CGCCCACCCC CTTACACACC 
CAGGTCCAGA GCTCGGCCGC CCAGCAGCCG CCGCCAGCCT CAGCAGCCCC TAGAATGAGC 
ACTGTGGCCT CACAGATCCA GCAGGTCCCC GTTGTACTGC AGCCACACTT CATCAAGGCA 
GACTCGCTGC TGCTGACAGC TGTAAAGACA GACACAGGAG CCACAATGAA GACCGCAGGC 
ATCAACACCC TGGCTCCTGG CACAGCCGTG CAGGCAGGCC CCTTGCAGCT GAATAAATCT 
GCTGTCTTGC GCAAGGCCAT CGACTACATC CGCTTCTTAC AGCACAGCAA CCAGAAACTC 
AAGCAGGAGA ACCTGACCCT GCGAAGTGCT CACAAAAGCA AATCACTGAA AGACCTGGTG 
TCAGCTTGTG GCAGTGGAGG AGGCACAGAT GTGTCTATGG AGGGCATGAA ACCTGAAGTG 
GTAGAAACGC TGACCCCTCC ACCCTCAGAC GCCGGCTCAC CCTCCCAGAG TAGCCCCTTG 
TCCTTGGGCA GCAGAGGCAG CAGCAGTGGT GGCAGTGACT CTGAGCCCGA CAGCCCAGCC 
TTTGAGGATA ACCAGGTGAA AGCCCAGCGG CTGCCTTCAC ATAGCCGAGG CATGCTGGAC 
CGCTCCCGCC TGGCCCTGTG TGTACTGGTC TTCCTGTGTC TGACCTGCAA CCCATTGGCC 
TCACTGTTTG GCTGGGGCAT CCTCACTCCC TCTGATGCTT CGGGTGTGCA CCGTAGTTCT 
GGGCGCAGCA TGCTGGAGGC CGAGAGCAGA GATGGCTCTA ATTGGACCCA GTGGTTGCTG 
CCACCCCTAG TCTGGCTGGC CAATGGACTA CTAGTGTTGG CCTGCTTGGC TCTTCTCTTT 
GTCTACGGGG AACCTGTGAC CAGGCCACAC TCCGGCCCGG CTGTACACTT CTGGAGACAT 
CGCAAACAAG CTGACCTGGA TTTGGCCCGG GGAGATTTTG CCCAGGCCGC TCAACAGCTG 
TGGCTGGCCT TGCAAGCCCT GGGCCGGCCC CTGCCCACCT CAAACCTGGA TCTGGCCTGC 
AGCCTGCTTT GGAACCTCGT CCGCCACCTG CTGCAGCGTC TTTGGGTGGG CCGCTGGCTG 
GCAGGCCAGG CTGGGGGCCT GCAGAGGGAC TACAGGCTGA GAAAGGATGC TCGTGCCAGT 
GCCCGAGATG CGGCTGTCGT CTACCATAAG CTGCACCAGC TGCATGCCAT GGGCAAGTAC 
ACAGGAGGCC ATCTTGTTGC TTCTAACCTG GCACTGAGTG CCCTTAACCT GGCTGAGTGT 
GCAGGAGATG CTATATCCAT GGCAACACTG GCAGAGATCT ACGTGGCAGC TGCCCTAAGG 
GTCAAAACCA GCCTCCCCAG AGCCTTGCAC TTCTTGACAC GTTTCTTCCT GAGTAGTGCC 
CGCCAGGCCT GCCTGGCACA GAGTGGTGCA GTGCCTCTTG CCATGCAGTG GCTCTGCCAC 
CCTGTAGGTC ACCGTTTCTT CGTGGATGGG GACTGGGCTG TACACGGTGC CCCCCAGGAG 
AGTCTGTACA GCGTGGCTGG GAACCCAGTG GATCCACTGG CCCAGGTGAC CCGACTATTC 
TGTGAACATC TCCTGGAGCG AGCATTGAAC TGTATCGCTC AGCCCAGCCC AGGGGCAGCT 
GATGGAGACA GGGAGTTCTC AGATGCTCTT GGATATCTAC AGTTGCTAAA TAGCTGTTCT 
GACGCTGTCG GAGCTCCTGC GTGCAGCTTC TCTGTCAGTT CCAGCATGGC TACCACCACT 
GGCACAGACC CAGTGGCCAA GTGGTGGGCC TCACTGACAG CCGTGGTGAT CCACTGGCTG 
AGGCGGGATG AGGAGGCAGC TGAACGCTTA TACCCACTGG TAGAGCACAT TCCCCAAGTG 
CTGCAGGAAA CTGAGAGACC CCTTCCCAGG GCAGCTCTGT ACTCCTTCAA GGCTGCCCGG 
GCTCTGCTGG ACCACAGAAA GGTGGAATCC AGCCCAGCCA GCCTGGCCAT CTGTGAGAAG 
GCCAGTGGGT ACCTGCGGGA CAGCTTAGCC TCTACATCAA CTGCCAGTTC CATTGACAAG 
GCCATGCAGC TGCTCCTGTG TGATCTACTT CTTGTGGCCC GCACCAGCCT ATGGCGGCGC 
CAACAGTCAG CAGCTTCAGC CCAGGGAGCT CACGGTACCA GCAATGGACC CCAGGCCTCT 
GCTCTGGAGC TGCGTGGTTT CCAACATGAC CTGAGCAGCC TGAGGCGCTT GGCACAGAGC 
TTCCGGCCTG CTATGAGGAG GGTCTTCCTA CATGAGGCCA CAGCTCGGCT GATGGCAGGA 
GCAAGTCCTG CCCGGACACA CCAGCTCCTG GACCGCAGTC TGCGGAGGCG GGCAGGTTCC 
AGTGGCAAAG GAGGCGCTGC AGCTGAGCTG GAGCCTCGAC CCACATGGCG GGAGCACACA 
GAGGCCTTGC TGTTGGCCTC CTGCTATCTG CCCCCTGCCT TCCTGTCGGC CCCCGGGCAG 
CGAGTGAGCA TGCTGGCTGA GGCAGCGCGC ACCGTGGAGA AGCTTGGCGA TCACCGGCTC 
CTGCTTGACT GCCAGCAGAT GCTCCTGCGC CTGGGTGGCG GGACCACTGT CACTTCCAGC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017453030.1
CDS	93..3275
Translation	MDELPFGEAALEQALAEVCEMDAALLTDIEDMLQLINNQDSDFPGLFDAPYAGGETGDTGPSSPGASSPESFSSPASLGSSLEAFLGGPKVTPAPLSPPPSAPTAVKMYPSVPPFSPGPGIKEEPVPLTILQPPAPQPSPGTLLPPSFPPPPVQLSPAPVLGYSSLPSGFSGTLPGNTQQTPSSLPLGSTPGISPTPLHTQVQSSAAQQPPPASAAPRMSTVASQIQQVPVVLQPHFIKADSLLLTAVKTDTGATMKTAGINTLAPGTAVQAGPLQLNKSAVLRKAIDYIRFLQHSNQKLKQENLTLRSAHKSKSLKDLVSACGSGGGTDVSMEGMKPEVVETLTPPPSDAGSPSQSSPLSLGSRGSSSGGSDSEPDSPAFEDNQVKAQRLPSHSRGMLDRSRLALCVLVFLCLTCNPLASLFGWGILTPSDASGVHRSSGRSMLEAESRDGSNWTQWLLPPLVWLANGLLVLACLALLFVYGEPVTRPHSGPAVHFWRHRKQADLDLARGDFAQAAQQLWLALQALGRPLPTSNLDLACSLLWNLVRHLLQRLWVGRWLAGQAGGLQRDYRLRKDARASARDAAVVYHKLHQLHAMGKYTGGHLVASNLALSALNLAECAGDAISMATLAEIYVAAALRVKTSLPRALHFLTRFFLSSARQACLAQSGAVPLAMQWLCHPVGHRFFVDGDWAVHGAPQESLYSVAGNPVDPLAQVTRLFCEHLLERALNCIAQPSPGAADGDREFSDALGYLQLLNSCSDAVGAPACSFSVSSSMATTTGTDPVAKWWASLTAVVIHWLRRDEEAAERLYPLVEHIPQVLQETERPLPRAALYSFKAARALLDHRKVESSPASLAICEKASGYLRDSLASTSTASSIDKAMQLLLCDLLLVARTSLWRRQQSAASAQGAHGTSNGPQASALELRGFQHDLSSLRRLAQSFRPAMRRVFLHEATARLMAGASPARTHQLLDRSLRRRAGSSGKGGAAAELEPRPTWREHTEALLLASCYLPPAFLSAPGQRVSMLAEAARTVEKLGDHRLLLDCQQMLLRLGGGTTVTSS

Target ORF information:

RefSeq Version	XM_017597541.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597541.1

ORF Insert Sequence:

ATGGACGAGC TACCCTTCGG TGAGGCGGCT CTGGAACAGG CACTGGCCGA GGTGTGCGAA 
ATGGACGCGG CGCTCTTGAC CGACATCGAA GACATGCTTC AGCTCATCAA CAACCAAGAC 
AGTGACTTCC CTGGCCTATT TGATGCCCCC TATGCTGGGG GTGAGACAGG AGACACAGGC 
CCCAGCAGCC CTGGTGCCAG CTCTCCTGAG AGCTTCTCTT CTCCTGCTTC TCTGGGCTCC 
TCTCTGGAAG CCTTCCTGGG AGGACCCAAG GTGACACCTG CACCCTTGTC CCCTCCACCA 
TCGGCACCCA CTGCTGTAAA GATGTACCCG TCCGTGCCCC CCTTCTCCCC TGGGCCTGGA 
ATCAAAGAGG AGCCAGTGCC ACTCACCATC CTGCAGCCCC CAGCACCACA GCCATCGCCA 
GGGACCCTGT TGCCTCCGAG CTTCCCTCCT CCACCTGTGC AGCTCAGCCC TGCTCCTGTG 
CTGGGGTACT CAAGCCTGCC TTCCGGCTTC TCAGGAACCC TTCCTGGGAA CACCCAGCAG 
ACGCCATCTA GCCTGCCACT GGGCTCCACG CCAGGAATCT CGCCCACCCC CTTACACACC 
CAGGTCCAGA GCTCGGCCGC CCAGCAGCCG CCGCCAGCCT CAGCAGCCCC TAGAATGAGC 
ACTGTGGCCT CACAGATCCA GCAGGTCCCC GTTGTACTGC AGCCACACTT CATCAAGGCA 
GACTCGCTGC TGCTGACAGC TGTAAAGACA GACACAGGAG CCACAATGAA GACCGCAGGC 
ATCAACACCC TGGCTCCTGG CACAGCCGTG CAGGCAGGCC CCTTGCAGCT GAATAAATCT 
GCTGTCTTGC GCAAGGCCAT CGACTACATC CGCTTCTTAC AGCACAGCAA CCAGAAACTC 
AAGCAGGAGA ACCTGACCCT GCGAAGTGCT CACAAAAGCA AATCACTGAA AGACCTGGTG 
TCAGCTTGTG GCAGTGGAGG AGGCACAGAT GTGTCTATGG AGGGCATGAA ACCTGAAGTG 
GTAGAAACGC TGACCCCTCC ACCCTCAGAC GCCGGCTCAC CCTCCCAGAG TAGCCCCTTG 
TCCTTGGGCA GCAGAGGCAG CAGCAGTGGT GGCAGTGACT CTGAGCCCGA CAGCCCAGCC 
TTTGAGGATA ACCAGGTGAA AGCCCAGCGG CTGCCTTCAC ATAGCCGAGG CATGCTGGAC 
CGCTCCCGCC TGGCCCTGTG TGTACTGGTC TTCCTGTGTC TGACCTGCAA CCCATTGGCC 
TCACTGTTTG GCTGGGGCAT CCTCACTCCC TCTGATGCTT CGGGTGTGCA CCGTAGTTCT 
GGGCGCAGCA TGCTGGAGGC CGAGAGCAGA GATGGCTCTA ATTGGACCCA GTGGTTGCTG 
CCACCCCTAG TCTGGCTGGC CAATGGACTA CTAGTGTTGG CCTGCTTGGC TCTTCTCTTT 
GTCTACGGGG AACCTGTGAC CAGGCCACAC TCCGGCCCGG CTGTACACTT CTGGAGACAT 
CGCAAACAAG CTGACCTGGA TTTGGCCCGG GGAGATTTTG CCCAGGCCGC TCAACAGCTG 
TGGCTGGCCT TGCAAGCCCT GGGCCGGCCC CTGCCCACCT CAAACCTGGA TCTGGCCTGC 
AGCCTGCTTT GGAACCTCGT CCGCCACCTG CTGCAGCGTC TTTGGGTGGG CCGCTGGCTG 
GCAGGCCAGG CTGGGGGCCT GCAGAGGGAC TACAGGCTGA GAAAGGATGC TCGTGCCAGT 
GCCCGAGATG CGGCTGTCGT CTACCATAAG CTGCACCAGC TGCATGCCAT GGGCAAGTAC 
ACAGGAGGCC ATCTTGTTGC TTCTAACCTG GCACTGAGTG CCCTTAACCT GGCTGAGTGT 
GCAGGAGATG CTATATCCAT GGCAACACTG GCAGAGATCT ACGTGGCAGC TGCCCTAAGG 
GTCAAAACCA GCCTCCCCAG AGCCTTGCAC TTCTTGACAC GTTTCTTCCT GAGTAGTGCC 
CGCCAGGCCT GCCTGGCACA GAGTGGTGCA GTGCCTCTTG CCATGCAGTG GCTCTGCCAC 
CCTGTAGGTC ACCGTTTCTT CGTGGATGGG GACTGGGCTG TACACGGTGC CCCCCAGGAG 
AGTCTGTACA GCGTGGCTGG GAACCCAGTG GATCCACTGG CCCAGGTGAC CCGACTATTC 
TGTGAACATC TCCTGGAGCG AGCATTGAAC TGTATCGCTC AGCCCAGCCC AGGGGCAGCT 
GATGGAGACA GGGAGTTCTC AGATGCTCTT GGATATCTAC AGTTGCTAAA TAGCTGTTCT 
GACGCTGTCG GAGCTCCTGC GTGCAGCTTC TCTGTCAGTT CCAGCATGGC TACCACCACT 
GGCACAGACC CAGTGGCCAA GTGGTGGGCC TCACTGACAG CCGTGGTGAT CCACTGGCTG 
AGGCGGGATG AGGAGGCAGC TGAACGCTTA TACCCACTGG TAGAGCACAT TCCCCAAGTG 
CTGCAGGAAA CTGAGAGACC CCTTCCCAGG GCAGCTCTGT ACTCCTTCAA GGCTGCCCGG 
GCTCTGCTGG ACCACAGAAA GGTGGAATCC AGCCCAGCCA GCCTGGCCAT CTGTGAGAAG 
GCCAGTGGGT ACCTGCGGGA CAGCTTAGCC TCTACATCAA CTGCCAGTTC CATTGACAAG 
GCCATGCAGC TGCTCCTGTG TGATCTACTT CTTGTGGCCC GCACCAGCCT ATGGCGGCGC 
CAACAGTCAG CAGCTTCAGC CCAGGGAGCT CACGGTACCA GCAATGGACC CCAGGCCTCT 
GCTCTGGAGC TGCGTGGTTT CCAACATGAC CTGAGCAGCC TGAGGCGCTT GGCACAGAGC 
TTCCGGCCTG CTATGAGGAG GGTCTTCCTA CATGAGGCCA CAGCTCGGCT GATGGCAGGA 
GCAAGTCCTG CCCGGACACA CCAGCTCCTG GACCGCAGTC TGCGGAGGCG GGCAGGTTCC 
AGTGGCAAAG GAGGCGCTGC AGCTGAGCTG GAGCCTCGAC CCACATGGCG GGAGCACACA 
GAGGCCTTGC TGTTGGCCTC CTGCTATCTG CCCCCTGCCT TCCTGTCGGC CCCCGGGCAG 
CGAGTGAGCA TGCTGGCTGA GGCAGCGCGC ACCGTGGAGA AGCTTGGCGA TCACCGGCTC 
CTGCTTGACT GCCAGCAGAT GCTCCTGCGC CTGGGTGGCG GGACCACTGT CACTTCCAGC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Srebf1 ( NM_001276707.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001263636.1 Rattus norvegicus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa12263
Clone ID Related Accession (Same CDS sequence)	NM_001276707.1
Accession Version	NM_001276707.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	sterol regulatory element-binding protein 1 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC128154.4. On or before Feb 28, 2013 this sequence version replaced XM_213329.6, XM_001075680.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACGAGC TACCCTTCGG TGAGGCGGCT CTGGAACAGG CACTGGCCGA GGTGTGCGAA 
ATGGACGCGG CGCTCTTGAC CGACATCGAA GACATGCTTC AGCTCATCAA CAACCAAGAC 
AGTGACTTCC CTGGCCTATT TGATGCCCCC TATGCTGGGG GTGAGACAGG AGACACAGGC 
CCCAGCAGCC CTGGTGCCAG CTCTCCTGAG AGCTTCTCTT CTCCTGCTTC TCTGGGCTCC 
TCTCTGGAAG CCTTCCTGGG AGGACCCAAG GTGACACCTG CACCCTTGTC CCCTCCACCA 
TCGGCACCCA CTGCTGTAAA GATGTACCCG TCCGTGCCCC CCTTCTCCCC TGGGCCTGGA 
ATCAAAGAGG AGCCAGTGCC ACTCACCATC CTGCAGCCCC CAGCACCACA GCCATCGCCA 
GGGACCCTGT TGCCTCCGAG CTTCCCTCCT CCACCTGTGC AGCTCAGCCC TGCTCCTGTG 
CTGGGGTACT CAAGCCTGCC TTCCGGCTTC TCAGGAACCC TTCCTGGGAA CACCCAGCAG 
ACGCCATCTA GCCTGCCACT GGGCTCCACG CCAGGAATCT CGCCCACCCC CTTACACACC 
CAGGTCCAGA GCTCGGCCGC CCAGCAGCCG CCGCCAGCCT CAGCAGCCCC TAGAATGAGC 
ACTGTGGCCT CACAGATCCA GCAGGTCCCC GTTGTACTGC AGCCACACTT CATCAAGGCA 
GACTCGCTGC TGCTGACAGC TGTAAAGACA GACACAGGAG CCACAATGAA GACCGCAGGC 
ATCAACACCC TGGCTCCTGG CACAGCCGTG CAGGCAGGCC CCTTGCAGAC CCTGGTGAGT 
GGAGGGACCA TCCTGGCCAC AGTACCACTG GTTGTGGACA CAGACAAACT GCCCATCCAC 
CGACTAGCAG CTGGTGGCAA GGCCCTGGGC TCAGCTCAGA GCCGTGGTGA GAAGCGCACA 
GCCCACAATG CCATTGAGAA GCGCTACCGT TCCTCTATCA ATGACAAGAT TGTGGAGCTC 
AAGGACCTGG TGGTGGGCAC TGAGGCAAAG CTGAATAAAT CTGCTGTCTT GCGCAAGGCC 
ATCGACTACA TCCGCTTCTT ACAGCACAGC AACCAGAAAC TCAAGCAGGA GAACCTGACC 
CTGCGAAGTG CTCACAAAAG CAAATCACTG AAAGACCTGG TGTCAGCTTG TGGCAGTGGA 
GGAGGCACAG ATGTGTCTAT GGAGGGCATG AAACCTGAAG TGGTAGAAAC GCTGACCCCT 
CCACCCTCAG ACGCCGGCTC ACCCTCCCAG AGTAGCCCCT TGTCCTTGGG CAGCAGAGGC 
AGCAGCAGTG GTGGCAGTGA CTCTGAGCCC GACAGCCCAG CCTTTGAGGA TAACCAGGTG 
AAAGCCCAGC GGCTGCCTTC ACATAGCCGA GGCATGCTGG ACCGCTCCCG CCTGGCCCTG 
TGTGTACTGG TCTTCCTGTG TCTGACCTGC AACCCATTGG CCTCACTGTT TGGCTGGGGC 
ATCCTCACTC CCTCTGATGC TTCGGGTGTG CACCGTAGTT CTGGGCGCAG CATGCTGGAG 
GCCGAGAGCA GAGATGGCTC TAATTGGACC CAGTGGTTGC TGCCACCCCT AGTCTGGCTG 
GCCAATGGAC TACTAGTGTT GGCCTGCTTG GCTCTTCTCT TTGTCTACGG GGAACCTGTG 
ACCAGGCCAC ACTCCGGCCC GGCTGTACAC TTCTGGAGAC ATCGCAAACA AGCTGACCTG 
GATTTGGCCC GGGGAGATTT TGCCCAGGCC GCTCAACAGC TGTGGCTGGC CTTGCAAGCC 
CTGGGCCGGC CCCTGCCCAC CTCAAACCTG GATCTGGCCT GCAGCCTGCT TTGGAACCTC 
GTCCGCCACC TGCTGCAGCG TCTTTGGGTG GGCCGCTGGC TGGCAGGCCA GGCTGGGGGC 
CTGCAGAGGG ACTACAGGCT GAGAAAGGAT GCTCGTGCCA GTGCCCGAGA TGCGGCTGTC 
GTCTACCATA AGCTGCACCA GCTGCATGCC ATGGGCAAGT ACACAGGAGG CCATCTTGTT 
GCTTCTAACC TGGCACTGAG TGCCCTTAAC CTGGCTGAGT GTGCAGGAGA TGCTATATCC 
ATGGCAACAC TGGCAGAGAT CTACGTGGCA GCTGCCCTAA GGGTCAAAAC CAGCCTCCCC 
AGAGCCTTGC ACTTCTTGAC ACGTTTCTTC CTGAGTAGTG CCCGCCAGGC CTGCCTGGCA 
CAGAGTGGTG CAGTGCCTCT TGCCATGCAG TGGCTCTGCC ACCCTGTAGG TCACCGTTTC 
TTCGTGGATG GGGACTGGGC TGTACACGGT GCCCCCCAGG AGAGTCTGTA CAGCGTGGCT 
GGGAACCCAG TGGATCCACT GGCCCAGGTG ACCCGACTAT TCTGTGAACA TCTCCTGGAG 
CGAGCATTGA ACTGTATCGC TCAGCCCAGC CCAGGGGCAG CTGATGGAGA CAGGGAGTTC 
TCAGATGCTC TTGGATATCT ACAGTTGCTA AATAGCTGTT CTGACGCTGT CGGAGCTCCT 
GCGTGCAGCT TCTCTGTCAG TTCCAGCATG GCTACCACCA CTGGCACAGA CCCAGTGGCC 
AAGTGGTGGG CCTCACTGAC AGCCGTGGTG ATCCACTGGC TGAGGCGGGA TGAGGAGGCA 
GCTGAACGCT TATACCCACT GGTAGAGCAC ATTCCCCAAG TGCTGCAGGA AACTGAGAGA 
CCCCTTCCCA GGGCAGCTCT GTACTCCTTC AAGGCTGCCC GGGCTCTGCT GGACCACAGA 
AAGGTGGAAT CCAGCCCAGC CAGCCTGGCC ATCTGTGAGA AGGCCAGTGG GTACCTGCGG 
GACAGCTTAG CCTCTACATC AACTGCCAGT TCCATTGACA AGGCCATGCA GCTGCTCCTG 
TGTGATCTAC TTCTTGTGGC CCGCACCAGC CTATGGCGGC GCCAACAGTC AGCAGCTTCA 
GCCCAGGGAG CTCACGGTAC CAGCAATGGA CCCCAGGCCT CTGCTCTGGA GCTGCGTGGT 
TTCCAACATG ACCTGAGCAG CCTGAGGCGC TTGGCACAGA GCTTCCGGCC TGCTATGAGG 
AGGGTCTTCC TACATGAGGC CACAGCTCGG CTGATGGCAG GAGCAAGTCC TGCCCGGACA 
CACCAGCTCC TGGACCGCAG TCTGCGGAGG CGGGCAGGTT CCAGTGGCAA AGGAGGCGCT 
GCAGCTGAGC TGGAGCCTCG ACCCACATGG CGGGAGCACA CAGAGGCCTT GCTGTTGGCC 
TCCTGCTATC TGCCCCCTGC CTTCCTGTCG GCCCCCGGGC AGCGAGTGAG CATGCTGGCT 
GAGGCAGCGC GCACCGTGGA GAAGCTTGGC GATCACCGGC TCCTGCTTGA CTGCCAGCAG 
ATGCTCCTGC GCCTGGGTGG CGGGACCACT GTCACTTCCA GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001263636.1
CDS	81..3485
Translation	MDELPFGEAALEQALAEVCEMDAALLTDIEDMLQLINNQDSDFPGLFDAPYAGGETGDTGPSSPGASSPESFSSPASLGSSLEAFLGGPKVTPAPLSPPPSAPTAVKMYPSVPPFSPGPGIKEEPVPLTILQPPAPQPSPGTLLPPSFPPPPVQLSPAPVLGYSSLPSGFSGTLPGNTQQTPSSLPLGSTPGISPTPLHTQVQSSAAQQPPPASAAPRMSTVASQIQQVPVVLQPHFIKADSLLLTAVKTDTGATMKTAGINTLAPGTAVQAGPLQTLVSGGTILATVPLVVDTDKLPIHRLAAGGKALGSAQSRGEKRTAHNAIEKRYRSSINDKIVELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLTLRSAHKSKSLKDLVSACGSGGGTDVSMEGMKPEVVETLTPPPSDAGSPSQSSPLSLGSRGSSSGGSDSEPDSPAFEDNQVKAQRLPSHSRGMLDRSRLALCVLVFLCLTCNPLASLFGWGILTPSDASGVHRSSGRSMLEAESRDGSNWTQWLLPPLVWLANGLLVLACLALLFVYGEPVTRPHSGPAVHFWRHRKQADLDLARGDFAQAAQQLWLALQALGRPLPTSNLDLACSLLWNLVRHLLQRLWVGRWLAGQAGGLQRDYRLRKDARASARDAAVVYHKLHQLHAMGKYTGGHLVASNLALSALNLAECAGDAISMATLAEIYVAAALRVKTSLPRALHFLTRFFLSSARQACLAQSGAVPLAMQWLCHPVGHRFFVDGDWAVHGAPQESLYSVAGNPVDPLAQVTRLFCEHLLERALNCIAQPSPGAADGDREFSDALGYLQLLNSCSDAVGAPACSFSVSSSMATTTGTDPVAKWWASLTAVVIHWLRRDEEAAERLYPLVEHIPQVLQETERPLPRAALYSFKAARALLDHRKVESSPASLAICEKASGYLRDSLASTSTASSIDKAMQLLLCDLLLVARTSLWRRQQSAASAQGAHGTSNGPQASALELRGFQHDLSSLRRLAQSFRPAMRRVFLHEATARLMAGASPARTHQLLDRSLRRRAGSSGKGGAAAELEPRPTWREHTEALLLASCYLPPAFLSAPGQRVSMLAEAARTVEKLGDHRLLLDCQQMLLRLGGGTTVTSS

Target ORF information:

RefSeq Version	NM_001276707.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001276707.1

ORF Insert Sequence:

ATGGACGAGC TACCCTTCGG TGAGGCGGCT CTGGAACAGG CACTGGCCGA GGTGTGCGAA 
ATGGACGCGG CGCTCTTGAC CGACATCGAA GACATGCTTC AGCTCATCAA CAACCAAGAC 
AGTGACTTCC CTGGCCTATT TGATGCCCCC TATGCTGGGG GTGAGACAGG AGACACAGGC 
CCCAGCAGCC CTGGTGCCAG CTCTCCTGAG AGCTTCTCTT CTCCTGCTTC TCTGGGCTCC 
TCTCTGGAAG CCTTCCTGGG AGGACCCAAG GTGACACCTG CACCCTTGTC CCCTCCACCA 
TCGGCACCCA CTGCTGTAAA GATGTACCCG TCCGTGCCCC CCTTCTCCCC TGGGCCTGGA 
ATCAAAGAGG AGCCAGTGCC ACTCACCATC CTGCAGCCCC CAGCACCACA GCCATCGCCA 
GGGACCCTGT TGCCTCCGAG CTTCCCTCCT CCACCTGTGC AGCTCAGCCC TGCTCCTGTG 
CTGGGGTACT CAAGCCTGCC TTCCGGCTTC TCAGGAACCC TTCCTGGGAA CACCCAGCAG 
ACGCCATCTA GCCTGCCACT GGGCTCCACG CCAGGAATCT CGCCCACCCC CTTACACACC 
CAGGTCCAGA GCTCGGCCGC CCAGCAGCCG CCGCCAGCCT CAGCAGCCCC TAGAATGAGC 
ACTGTGGCCT CACAGATCCA GCAGGTCCCC GTTGTACTGC AGCCACACTT CATCAAGGCA 
GACTCGCTGC TGCTGACAGC TGTAAAGACA GACACAGGAG CCACAATGAA GACCGCAGGC 
ATCAACACCC TGGCTCCTGG CACAGCCGTG CAGGCAGGCC CCTTGCAGAC CCTGGTGAGT 
GGAGGGACCA TCCTGGCCAC AGTACCACTG GTTGTGGACA CAGACAAACT GCCCATCCAC 
CGACTAGCAG CTGGTGGCAA GGCCCTGGGC TCAGCTCAGA GCCGTGGTGA GAAGCGCACA 
GCCCACAATG CCATTGAGAA GCGCTACCGT TCCTCTATCA ATGACAAGAT TGTGGAGCTC 
AAGGACCTGG TGGTGGGCAC TGAGGCAAAG CTGAATAAAT CTGCTGTCTT GCGCAAGGCC 
ATCGACTACA TCCGCTTCTT ACAGCACAGC AACCAGAAAC TCAAGCAGGA GAACCTGACC 
CTGCGAAGTG CTCACAAAAG CAAATCACTG AAAGACCTGG TGTCAGCTTG TGGCAGTGGA 
GGAGGCACAG ATGTGTCTAT GGAGGGCATG AAACCTGAAG TGGTAGAAAC GCTGACCCCT 
CCACCCTCAG ACGCCGGCTC ACCCTCCCAG AGTAGCCCCT TGTCCTTGGG CAGCAGAGGC 
AGCAGCAGTG GTGGCAGTGA CTCTGAGCCC GACAGCCCAG CCTTTGAGGA TAACCAGGTG 
AAAGCCCAGC GGCTGCCTTC ACATAGCCGA GGCATGCTGG ACCGCTCCCG CCTGGCCCTG 
TGTGTACTGG TCTTCCTGTG TCTGACCTGC AACCCATTGG CCTCACTGTT TGGCTGGGGC 
ATCCTCACTC CCTCTGATGC TTCGGGTGTG CACCGTAGTT CTGGGCGCAG CATGCTGGAG 
GCCGAGAGCA GAGATGGCTC TAATTGGACC CAGTGGTTGC TGCCACCCCT AGTCTGGCTG 
GCCAATGGAC TACTAGTGTT GGCCTGCTTG GCTCTTCTCT TTGTCTACGG GGAACCTGTG 
ACCAGGCCAC ACTCCGGCCC GGCTGTACAC TTCTGGAGAC ATCGCAAACA AGCTGACCTG 
GATTTGGCCC GGGGAGATTT TGCCCAGGCC GCTCAACAGC TGTGGCTGGC CTTGCAAGCC 
CTGGGCCGGC CCCTGCCCAC CTCAAACCTG GATCTGGCCT GCAGCCTGCT TTGGAACCTC 
GTCCGCCACC TGCTGCAGCG TCTTTGGGTG GGCCGCTGGC TGGCAGGCCA GGCTGGGGGC 
CTGCAGAGGG ACTACAGGCT GAGAAAGGAT GCTCGTGCCA GTGCCCGAGA TGCGGCTGTC 
GTCTACCATA AGCTGCACCA GCTGCATGCC ATGGGCAAGT ACACAGGAGG CCATCTTGTT 
GCTTCTAACC TGGCACTGAG TGCCCTTAAC CTGGCTGAGT GTGCAGGAGA TGCTATATCC 
ATGGCAACAC TGGCAGAGAT CTACGTGGCA GCTGCCCTAA GGGTCAAAAC CAGCCTCCCC 
AGAGCCTTGC ACTTCTTGAC ACGTTTCTTC CTGAGTAGTG CCCGCCAGGC CTGCCTGGCA 
CAGAGTGGTG CAGTGCCTCT TGCCATGCAG TGGCTCTGCC ACCCTGTAGG TCACCGTTTC 
TTCGTGGATG GGGACTGGGC TGTACACGGT GCCCCCCAGG AGAGTCTGTA CAGCGTGGCT 
GGGAACCCAG TGGATCCACT GGCCCAGGTG ACCCGACTAT TCTGTGAACA TCTCCTGGAG 
CGAGCATTGA ACTGTATCGC TCAGCCCAGC CCAGGGGCAG CTGATGGAGA CAGGGAGTTC 
TCAGATGCTC TTGGATATCT ACAGTTGCTA AATAGCTGTT CTGACGCTGT CGGAGCTCCT 
GCGTGCAGCT TCTCTGTCAG TTCCAGCATG GCTACCACCA CTGGCACAGA CCCAGTGGCC 
AAGTGGTGGG CCTCACTGAC AGCCGTGGTG ATCCACTGGC TGAGGCGGGA TGAGGAGGCA 
GCTGAACGCT TATACCCACT GGTAGAGCAC ATTCCCCAAG TGCTGCAGGA AACTGAGAGA 
CCCCTTCCCA GGGCAGCTCT GTACTCCTTC AAGGCTGCCC GGGCTCTGCT GGACCACAGA 
AAGGTGGAAT CCAGCCCAGC CAGCCTGGCC ATCTGTGAGA AGGCCAGTGG GTACCTGCGG 
GACAGCTTAG CCTCTACATC AACTGCCAGT TCCATTGACA AGGCCATGCA GCTGCTCCTG 
TGTGATCTAC TTCTTGTGGC CCGCACCAGC CTATGGCGGC GCCAACAGTC AGCAGCTTCA 
GCCCAGGGAG CTCACGGTAC CAGCAATGGA CCCCAGGCCT CTGCTCTGGA GCTGCGTGGT 
TTCCAACATG ACCTGAGCAG CCTGAGGCGC TTGGCACAGA GCTTCCGGCC TGCTATGAGG 
AGGGTCTTCC TACATGAGGC CACAGCTCGG CTGATGGCAG GAGCAAGTCC TGCCCGGACA 
CACCAGCTCC TGGACCGCAG TCTGCGGAGG CGGGCAGGTT CCAGTGGCAA AGGAGGCGCT 
GCAGCTGAGC TGGAGCCTCG ACCCACATGG CGGGAGCACA CAGAGGCCTT GCTGTTGGCC 
TCCTGCTATC TGCCCCCTGC CTTCCTGTCG GCCCCCGGGC AGCGAGTGAG CATGCTGGCT 
GAGGCAGCGC GCACCGTGGA GAAGCTTGGC GATCACCGGC TCCTGCTTGA CTGCCAGCAG 
ATGCTCCTGC GCCTGGGTGG CGGGACCACT GTCACTTCCA GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Srebf1 ( NM_001276708.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001263637.1 Rattus norvegicus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant 2, mRNA.

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CloneID	ORa12273
Clone ID Related Accession (Same CDS sequence)	NM_001276708.1
Accession Version	NM_001276708.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Rattus norvegicus(Norway rat)
Product	sterol regulatory element-binding protein 1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC128154.4. Transcript Variant: This variant (2) uses an alternate 5' exon structure, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGATTGCA CATTTGAAGA CATGCTTCAG CTCATCAACA ACCAAGACAG TGACTTCCCT 
GGCCTATTTG ATGCCCCCTA TGCTGGGGGT GAGACAGGAG ACACAGGCCC CAGCAGCCCT 
GGTGCCAGCT CTCCTGAGAG CTTCTCTTCT CCTGCTTCTC TGGGCTCCTC TCTGGAAGCC 
TTCCTGGGAG GACCCAAGGT GACACCTGCA CCCTTGTCCC CTCCACCATC GGCACCCACT 
GCTGTAAAGA TGTACCCGTC CGTGCCCCCC TTCTCCCCTG GGCCTGGAAT CAAAGAGGAG 
CCAGTGCCAC TCACCATCCT GCAGCCCCCA GCACCACAGC CATCGCCAGG GACCCTGTTG 
CCTCCGAGCT TCCCTCCTCC ACCTGTGCAG CTCAGCCCTG CTCCTGTGCT GGGGTACTCA 
AGCCTGCCTT CCGGCTTCTC AGGAACCCTT CCTGGGAACA CCCAGCAGAC GCCATCTAGC 
CTGCCACTGG GCTCCACGCC AGGAATCTCG CCCACCCCCT TACACACCCA GGTCCAGAGC 
TCGGCCGCCC AGCAGCCGCC GCCAGCCTCA GCAGCCCCTA GAATGAGCAC TGTGGCCTCA 
CAGATCCAGC AGGTCCCCGT TGTACTGCAG CCACACTTCA TCAAGGCAGA CTCGCTGCTG 
CTGACAGCTG TAAAGACAGA CACAGGAGCC ACAATGAAGA CCGCAGGCAT CAACACCCTG 
GCTCCTGGCA CAGCCGTGCA GGCAGGCCCC TTGCAGACCC TGGTGAGTGG AGGGACCATC 
CTGGCCACAG TACCACTGGT TGTGGACACA GACAAACTGC CCATCCACCG ACTAGCAGCT 
GGTGGCAAGG CCCTGGGCTC AGCTCAGAGC CGTGGTGAGA AGCGCACAGC CCACAATGCC 
ATTGAGAAGC GCTACCGTTC CTCTATCAAT GACAAGATTG TGGAGCTCAA GGACCTGGTG 
GTGGGCACTG AGGCAAAGCT GAATAAATCT GCTGTCTTGC GCAAGGCCAT CGACTACATC 
CGCTTCTTAC AGCACAGCAA CCAGAAACTC AAGCAGGAGA ACCTGACCCT GCGAAGTGCT 
CACAAAAGCA AATCACTGAA AGACCTGGTG TCAGCTTGTG GCAGTGGAGG AGGCACAGAT 
GTGTCTATGG AGGGCATGAA ACCTGAAGTG GTAGAAACGC TGACCCCTCC ACCCTCAGAC 
GCCGGCTCAC CCTCCCAGAG TAGCCCCTTG TCCTTGGGCA GCAGAGGCAG CAGCAGTGGT 
GGCAGTGACT CTGAGCCCGA CAGCCCAGCC TTTGAGGATA ACCAGGTGAA AGCCCAGCGG 
CTGCCTTCAC ATAGCCGAGG CATGCTGGAC CGCTCCCGCC TGGCCCTGTG TGTACTGGTC 
TTCCTGTGTC TGACCTGCAA CCCATTGGCC TCACTGTTTG GCTGGGGCAT CCTCACTCCC 
TCTGATGCTT CGGGTGTGCA CCGTAGTTCT GGGCGCAGCA TGCTGGAGGC CGAGAGCAGA 
GATGGCTCTA ATTGGACCCA GTGGTTGCTG CCACCCCTAG TCTGGCTGGC CAATGGACTA 
CTAGTGTTGG CCTGCTTGGC TCTTCTCTTT GTCTACGGGG AACCTGTGAC CAGGCCACAC 
TCCGGCCCGG CTGTACACTT CTGGAGACAT CGCAAACAAG CTGACCTGGA TTTGGCCCGG 
GGAGATTTTG CCCAGGCCGC TCAACAGCTG TGGCTGGCCT TGCAAGCCCT GGGCCGGCCC 
CTGCCCACCT CAAACCTGGA TCTGGCCTGC AGCCTGCTTT GGAACCTCGT CCGCCACCTG 
CTGCAGCGTC TTTGGGTGGG CCGCTGGCTG GCAGGCCAGG CTGGGGGCCT GCAGAGGGAC 
TACAGGCTGA GAAAGGATGC TCGTGCCAGT GCCCGAGATG CGGCTGTCGT CTACCATAAG 
CTGCACCAGC TGCATGCCAT GGGCAAGTAC ACAGGAGGCC ATCTTGTTGC TTCTAACCTG 
GCACTGAGTG CCCTTAACCT GGCTGAGTGT GCAGGAGATG CTATATCCAT GGCAACACTG 
GCAGAGATCT ACGTGGCAGC TGCCCTAAGG GTCAAAACCA GCCTCCCCAG AGCCTTGCAC 
TTCTTGACAC GTTTCTTCCT GAGTAGTGCC CGCCAGGCCT GCCTGGCACA GAGTGGTGCA 
GTGCCTCTTG CCATGCAGTG GCTCTGCCAC CCTGTAGGTC ACCGTTTCTT CGTGGATGGG 
GACTGGGCTG TACACGGTGC CCCCCAGGAG AGTCTGTACA GCGTGGCTGG GAACCCAGTG 
GATCCACTGG CCCAGGTGAC CCGACTATTC TGTGAACATC TCCTGGAGCG AGCATTGAAC 
TGTATCGCTC AGCCCAGCCC AGGGGCAGCT GATGGAGACA GGGAGTTCTC AGATGCTCTT 
GGATATCTAC AGTTGCTAAA TAGCTGTTCT GACGCTGTCG GAGCTCCTGC GTGCAGCTTC 
TCTGTCAGTT CCAGCATGGC TACCACCACT GGCACAGACC CAGTGGCCAA GTGGTGGGCC 
TCACTGACAG CCGTGGTGAT CCACTGGCTG AGGCGGGATG AGGAGGCAGC TGAACGCTTA 
TACCCACTGG TAGAGCACAT TCCCCAAGTG CTGCAGGAAA CTGAGAGACC CCTTCCCAGG 
GCAGCTCTGT ACTCCTTCAA GGCTGCCCGG GCTCTGCTGG ACCACAGAAA GGTGGAATCC 
AGCCCAGCCA GCCTGGCCAT CTGTGAGAAG GCCAGTGGGT ACCTGCGGGA CAGCTTAGCC 
TCTACATCAA CTGCCAGTTC CATTGACAAG GCCATGCAGC TGCTCCTGTG TGATCTACTT 
CTTGTGGCCC GCACCAGCCT ATGGCGGCGC CAACAGTCAG CAGCTTCAGC CCAGGGAGCT 
CACGGTACCA GCAATGGACC CCAGGCCTCT GCTCTGGAGC TGCGTGGTTT CCAACATGAC 
CTGAGCAGCC TGAGGCGCTT GGCACAGAGC TTCCGGCCTG CTATGAGGAG GGTCTTCCTA 
CATGAGGCCA CAGCTCGGCT GATGGCAGGA GCAAGTCCTG CCCGGACACA CCAGCTCCTG 
GACCGCAGTC TGCGGAGGCG GGCAGGTTCC AGTGGCAAAG GAGGCGCTGC AGCTGAGCTG 
GAGCCTCGAC CCACATGGCG GGAGCACACA GAGGCCTTGC TGTTGGCCTC CTGCTATCTG 
CCCCCTGCCT TCCTGTCGGC CCCCGGGCAG CGAGTGAGCA TGCTGGCTGA GGCAGCGCGC 
ACCGTGGAGA AGCTTGGCGA TCACCGGCTC CTGCTTGACT GCCAGCAGAT GCTCCTGCGC 
CTGGGTGGCG GGACCACTGT CACTTCCAGC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001263637.1
CDS	40..3372
Translation	MDCTFEDMLQLINNQDSDFPGLFDAPYAGGETGDTGPSSPGASSPESFSSPASLGSSLEAFLGGPKVTPAPLSPPPSAPTAVKMYPSVPPFSPGPGIKEEPVPLTILQPPAPQPSPGTLLPPSFPPPPVQLSPAPVLGYSSLPSGFSGTLPGNTQQTPSSLPLGSTPGISPTPLHTQVQSSAAQQPPPASAAPRMSTVASQIQQVPVVLQPHFIKADSLLLTAVKTDTGATMKTAGINTLAPGTAVQAGPLQTLVSGGTILATVPLVVDTDKLPIHRLAAGGKALGSAQSRGEKRTAHNAIEKRYRSSINDKIVELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLTLRSAHKSKSLKDLVSACGSGGGTDVSMEGMKPEVVETLTPPPSDAGSPSQSSPLSLGSRGSSSGGSDSEPDSPAFEDNQVKAQRLPSHSRGMLDRSRLALCVLVFLCLTCNPLASLFGWGILTPSDASGVHRSSGRSMLEAESRDGSNWTQWLLPPLVWLANGLLVLACLALLFVYGEPVTRPHSGPAVHFWRHRKQADLDLARGDFAQAAQQLWLALQALGRPLPTSNLDLACSLLWNLVRHLLQRLWVGRWLAGQAGGLQRDYRLRKDARASARDAAVVYHKLHQLHAMGKYTGGHLVASNLALSALNLAECAGDAISMATLAEIYVAAALRVKTSLPRALHFLTRFFLSSARQACLAQSGAVPLAMQWLCHPVGHRFFVDGDWAVHGAPQESLYSVAGNPVDPLAQVTRLFCEHLLERALNCIAQPSPGAADGDREFSDALGYLQLLNSCSDAVGAPACSFSVSSSMATTTGTDPVAKWWASLTAVVIHWLRRDEEAAERLYPLVEHIPQVLQETERPLPRAALYSFKAARALLDHRKVESSPASLAICEKASGYLRDSLASTSTASSIDKAMQLLLCDLLLVARTSLWRRQQSAASAQGAHGTSNGPQASALELRGFQHDLSSLRRLAQSFRPAMRRVFLHEATARLMAGASPARTHQLLDRSLRRRAGSSGKGGAAAELEPRPTWREHTEALLLASCYLPPAFLSAPGQRVSMLAEAARTVEKLGDHRLLLDCQQMLLRLGGGTTVTSS

Target ORF information:

RefSeq Version	NM_001276708.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001276708.1

ORF Insert Sequence:

ATGGATTGCA CATTTGAAGA CATGCTTCAG CTCATCAACA ACCAAGACAG TGACTTCCCT 
GGCCTATTTG ATGCCCCCTA TGCTGGGGGT GAGACAGGAG ACACAGGCCC CAGCAGCCCT 
GGTGCCAGCT CTCCTGAGAG CTTCTCTTCT CCTGCTTCTC TGGGCTCCTC TCTGGAAGCC 
TTCCTGGGAG GACCCAAGGT GACACCTGCA CCCTTGTCCC CTCCACCATC GGCACCCACT 
GCTGTAAAGA TGTACCCGTC CGTGCCCCCC TTCTCCCCTG GGCCTGGAAT CAAAGAGGAG 
CCAGTGCCAC TCACCATCCT GCAGCCCCCA GCACCACAGC CATCGCCAGG GACCCTGTTG 
CCTCCGAGCT TCCCTCCTCC ACCTGTGCAG CTCAGCCCTG CTCCTGTGCT GGGGTACTCA 
AGCCTGCCTT CCGGCTTCTC AGGAACCCTT CCTGGGAACA CCCAGCAGAC GCCATCTAGC 
CTGCCACTGG GCTCCACGCC AGGAATCTCG CCCACCCCCT TACACACCCA GGTCCAGAGC 
TCGGCCGCCC AGCAGCCGCC GCCAGCCTCA GCAGCCCCTA GAATGAGCAC TGTGGCCTCA 
CAGATCCAGC AGGTCCCCGT TGTACTGCAG CCACACTTCA TCAAGGCAGA CTCGCTGCTG 
CTGACAGCTG TAAAGACAGA CACAGGAGCC ACAATGAAGA CCGCAGGCAT CAACACCCTG 
GCTCCTGGCA CAGCCGTGCA GGCAGGCCCC TTGCAGACCC TGGTGAGTGG AGGGACCATC 
CTGGCCACAG TACCACTGGT TGTGGACACA GACAAACTGC CCATCCACCG ACTAGCAGCT 
GGTGGCAAGG CCCTGGGCTC AGCTCAGAGC CGTGGTGAGA AGCGCACAGC CCACAATGCC 
ATTGAGAAGC GCTACCGTTC CTCTATCAAT GACAAGATTG TGGAGCTCAA GGACCTGGTG 
GTGGGCACTG AGGCAAAGCT GAATAAATCT GCTGTCTTGC GCAAGGCCAT CGACTACATC 
CGCTTCTTAC AGCACAGCAA CCAGAAACTC AAGCAGGAGA ACCTGACCCT GCGAAGTGCT 
CACAAAAGCA AATCACTGAA AGACCTGGTG TCAGCTTGTG GCAGTGGAGG AGGCACAGAT 
GTGTCTATGG AGGGCATGAA ACCTGAAGTG GTAGAAACGC TGACCCCTCC ACCCTCAGAC 
GCCGGCTCAC CCTCCCAGAG TAGCCCCTTG TCCTTGGGCA GCAGAGGCAG CAGCAGTGGT 
GGCAGTGACT CTGAGCCCGA CAGCCCAGCC TTTGAGGATA ACCAGGTGAA AGCCCAGCGG 
CTGCCTTCAC ATAGCCGAGG CATGCTGGAC CGCTCCCGCC TGGCCCTGTG TGTACTGGTC 
TTCCTGTGTC TGACCTGCAA CCCATTGGCC TCACTGTTTG GCTGGGGCAT CCTCACTCCC 
TCTGATGCTT CGGGTGTGCA CCGTAGTTCT GGGCGCAGCA TGCTGGAGGC CGAGAGCAGA 
GATGGCTCTA ATTGGACCCA GTGGTTGCTG CCACCCCTAG TCTGGCTGGC CAATGGACTA 
CTAGTGTTGG CCTGCTTGGC TCTTCTCTTT GTCTACGGGG AACCTGTGAC CAGGCCACAC 
TCCGGCCCGG CTGTACACTT CTGGAGACAT CGCAAACAAG CTGACCTGGA TTTGGCCCGG 
GGAGATTTTG CCCAGGCCGC TCAACAGCTG TGGCTGGCCT TGCAAGCCCT GGGCCGGCCC 
CTGCCCACCT CAAACCTGGA TCTGGCCTGC AGCCTGCTTT GGAACCTCGT CCGCCACCTG 
CTGCAGCGTC TTTGGGTGGG CCGCTGGCTG GCAGGCCAGG CTGGGGGCCT GCAGAGGGAC 
TACAGGCTGA GAAAGGATGC TCGTGCCAGT GCCCGAGATG CGGCTGTCGT CTACCATAAG 
CTGCACCAGC TGCATGCCAT GGGCAAGTAC ACAGGAGGCC ATCTTGTTGC TTCTAACCTG 
GCACTGAGTG CCCTTAACCT GGCTGAGTGT GCAGGAGATG CTATATCCAT GGCAACACTG 
GCAGAGATCT ACGTGGCAGC TGCCCTAAGG GTCAAAACCA GCCTCCCCAG AGCCTTGCAC 
TTCTTGACAC GTTTCTTCCT GAGTAGTGCC CGCCAGGCCT GCCTGGCACA GAGTGGTGCA 
GTGCCTCTTG CCATGCAGTG GCTCTGCCAC CCTGTAGGTC ACCGTTTCTT CGTGGATGGG 
GACTGGGCTG TACACGGTGC CCCCCAGGAG AGTCTGTACA GCGTGGCTGG GAACCCAGTG 
GATCCACTGG CCCAGGTGAC CCGACTATTC TGTGAACATC TCCTGGAGCG AGCATTGAAC 
TGTATCGCTC AGCCCAGCCC AGGGGCAGCT GATGGAGACA GGGAGTTCTC AGATGCTCTT 
GGATATCTAC AGTTGCTAAA TAGCTGTTCT GACGCTGTCG GAGCTCCTGC GTGCAGCTTC 
TCTGTCAGTT CCAGCATGGC TACCACCACT GGCACAGACC CAGTGGCCAA GTGGTGGGCC 
TCACTGACAG CCGTGGTGAT CCACTGGCTG AGGCGGGATG AGGAGGCAGC TGAACGCTTA 
TACCCACTGG TAGAGCACAT TCCCCAAGTG CTGCAGGAAA CTGAGAGACC CCTTCCCAGG 
GCAGCTCTGT ACTCCTTCAA GGCTGCCCGG GCTCTGCTGG ACCACAGAAA GGTGGAATCC 
AGCCCAGCCA GCCTGGCCAT CTGTGAGAAG GCCAGTGGGT ACCTGCGGGA CAGCTTAGCC 
TCTACATCAA CTGCCAGTTC CATTGACAAG GCCATGCAGC TGCTCCTGTG TGATCTACTT 
CTTGTGGCCC GCACCAGCCT ATGGCGGCGC CAACAGTCAG CAGCTTCAGC CCAGGGAGCT 
CACGGTACCA GCAATGGACC CCAGGCCTCT GCTCTGGAGC TGCGTGGTTT CCAACATGAC 
CTGAGCAGCC TGAGGCGCTT GGCACAGAGC TTCCGGCCTG CTATGAGGAG GGTCTTCCTA 
CATGAGGCCA CAGCTCGGCT GATGGCAGGA GCAAGTCCTG CCCGGACACA CCAGCTCCTG 
GACCGCAGTC TGCGGAGGCG GGCAGGTTCC AGTGGCAAAG GAGGCGCTGC AGCTGAGCTG 
GAGCCTCGAC CCACATGGCG GGAGCACACA GAGGCCTTGC TGTTGGCCTC CTGCTATCTG 
CCCCCTGCCT TCCTGTCGGC CCCCGGGCAG CGAGTGAGCA TGCTGGCTGA GGCAGCGCGC 
ACCGTGGAGA AGCTTGGCGA TCACCGGCTC CTGCTTGACT GCCAGCAGAT GCTCCTGCGC 
CTGGGTGGCG GGACCACTGT CACTTCCAGC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Elevated sterol regulatory elementary binding protein 1 and GluA2 levels in the hippocampal nuclear fraction of Genetic Absence Epilepsy Rats from Strasbourg.
Epilepsy research1361-4(2017 Oct)
Sekar S,Omran E,Gopalakrishnan V,Howland JG,Snutch TP,Taghibiglou C

Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.
The Journal of biological chemistry292(26)10791-10800(2017 06)
Tajima-Shirasaki N,Ishii KA,Takayama H,Shirasaki T,Iwama H,Chikamoto K,Saito Y,Iwasaki Y,Teraguchi A,Lan F,Kikuchi A,Takeshita Y,Murao K,Matsugo S,Kaneko S,Misu H,Takamura T

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Srebf1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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