Fez1 cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Fez1 |
| Entrez Gene ID | 81730 |
| Full Name | fasciculation and elongation protein zeta 1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | fasciculation and elongation protein zeta-1; interacts with protein kinase C zeta; may play a role in axon guidance [RGD, Feb 2006]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| XM_017595930.1 | XP_017451419.1 | fasciculation and elongation protein zeta-1 isoform X1 |
| NM_031066.1 | NP_112328.1 | fasciculation and elongation protein zeta-1 |
| Homo sapiens (human) | FEZ1 | NP_005094.1 |
| Pan troglodytes (chimpanzee) | FEZ1 | XP_001145893.1 |
| Bos taurus (cattle) | FEZ1 | NP_001019693.1 |
| Mus musculus (house mouse) | Fez1 | NP_898994.2 |
| Gallus gallus (chicken) | FEZ1 | XP_423333.3 |
| Xenopus tropicalis (tropical clawed frog) | fez1 | NP_001072905.1 |
| Danio rerio (zebrafish) | fez1 | NP_998561.1 |
| FEZ1 | XP_002799887.1 | |
| Canis lupus familiaris (dog) | FEZ1 | XP_849234.1 |
| Rattus norvegicus (Norway rat) | Fez1 | NP_112328.1 |
Related articles in PubMed
Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking.
Butkevich E, H?rtig W, Nikolov M, Erck C, Grosche J, Urlaub H, Schmidt CF, Klopfenstein DR, Chua JJ
Scientific reports626965(2016 Jun)
Regulation of mitochondrial transport in neurons.
Lin MY, Sheng ZH
Experimental cell research334(1)35-44(2015 May)
Fasciculation and elongation protein zeta-1 (FEZ1) expression in reactive astrocytes in a rat model of Parkinson's disease.
Sun YY, Zhang Y, Sun XP, Liu TY, Liu ZH, Chen G, Xia CL
Neuropathology and applied neurobiology40(2)164-76(2014 Feb)
RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy.
Spang N, Feldmann A, Huesmann H, Bekbulat F, Schmitt V, Hiebel C, Koziollek-Drechsler I, Clement AM, Moosmann B, Jung J, Behrends C, Dikic I, Kern A, Behl C
Autophagy10(12)2297-309(2014)
The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection.
Haedicke J, Brown C, Naghavi MH
Proceedings of the National Academy of Sciences of the United States of America106(33)14040-5(2009 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
FEZ1 appears to represent a unique neuron-specific determinant of cellular susceptibility to infection in a cell type that is naturally resistant to HIV-1
Title: The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection.
Immunocytochemistry revealed that FEZ1 was located in the astrocytic cytoplasm and cell processes but not the nucleus
Title: Expression of fasciculation and elongation protein zeta-1 (FEZ1) in cultured rat neonatal astrocytes.
the FEZ1/kinesin complex functions for the transport of mitochondria along microtubules toward the extending neurites in differentiating PC12 cells.
Title: Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells.
Therefore, our results strongly suggest that FEZ1 participates in the establishment of neuronal polarity by controlling the mitochondrial motility along axon.
Title: Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility.
Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells.
Title: Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells.
The following Fez1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fez1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa07503 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017595930.1 , NM_031066.1 | |
| Accession Version | NM_031066.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | fasciculation and elongation protein zeta-1 | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U63740.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U63740.1, BC087740.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGAGGCTC CACTGGTGAG TCTGGATGAA GAGTTTGAAG ATATCAGGCC CTGCTGCACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_112328.1 |
| CDS | 155..1336 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_031066.1 |
ORF Insert Sequence:
1 | ATGGAGGCTC CACTGGTGAG TCTGGATGAA GAGTTTGAAG ATATCAGGCC CTGCTGCACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa07503 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017595930.1 , NM_031066.1 | |
| Accession Version | XM_017595930.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | fasciculation and elongation protein zeta-1 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGAGGCTC CACTGGTGAG TCTGGATGAA GAGTTTGAAG ATATCAGGCC CTGCTGCACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_017451419.1 |
| CDS | 509..1690 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_017595930.1 |
ORF Insert Sequence:
1 | ATGGAGGCTC CACTGGTGAG TCTGGATGAA GAGTTTGAAG ATATCAGGCC CTGCTGCACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking. |
|
Regulation of mitochondrial transport in neurons. |
|
Fasciculation and elongation protein zeta-1 (FEZ1) expression in reactive astrocytes in a rat model of Parkinson's disease. |
|
RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. |
|
The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection. |