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Pax8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Pax8
Entrez Gene ID 81819
Full Name paired box 8
General protein information
Preferred Names

paired box 8

Names

paired box protein Pax-8
Pax-8 protein
paired box gene 8
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

3

3p13
Summary acts as a redox regulated transcriptional activator [RGD, Feb 2006].

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_008761610.2 XP_008759832.1 paired box protein Pax-8 isoform X1
XM_006233646.3 XP_006233708.1 paired box protein Pax-8 isoform X1
NM_031141.2 NP_112403.2 paired box protein Pax-8
XM_008761611.2 XP_008759833.1 paired box protein Pax-8 isoform X2
XM_008761613.2 XP_008759835.1 paired box protein Pax-8 isoform X3

Pathways from BioSystems


Homologies


Danio rerio (zebrafish) pax8 XP_001339893.5
Bos taurus (cattle) PAX8 XP_002691446.2
Mus musculus (house mouse) Pax8 NP_035170.1
Xenopus tropicalis (tropical clawed frog) pax8 NP_001072769.2
Homo sapiens (human) PAX8 NP_003457.1
Rattus norvegicus (Norway rat) Pax8 NP_112403.2
Pan troglodytes (chimpanzee) PAX8 XP_003309249.2
PAX8 XP_001093559.1

Gene Ontology


Bibliography

Related articles in PubMed

Pax8 controls thyroid follicular polarity through cadherin-16.
Koumarianou P, Gom?z-L?pez G, Santisteban P
Journal of cell science130(1)219-231(2017 01)

Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells.
Lucci V, Di Palma T, Zannini M
PloS one10(6)e0128315(2015)

Pax8 modulates the expression of Wnt4 that is necessary for the maintenance of the epithelial phenotype of thyroid cells.
Filippone MG, Di Palma T, Lucci V, Zannini M
BMC molecular biology1521(2014 Sep)

Pax8 has a critical role in epithelial cell survival and proliferation.
Di Palma T, Filippone MG, Pierantoni GM, Fusco A, Soddu S, Zannini M
Cell death & disease4e729(2013 Jul)

Genome-wide analysis of Pax8 binding provides new insights into thyroid functions.
Ruiz-Llorente S, Carrillo Santa de Pau E, Sastre-Perona A, Montero-Conde C, G?mez-L?pez G, Fagin JA, Valencia A, Pisano DG, Santisteban P
BMC genomics13147(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pax8 controls apical-basal follicular polarization and follicle formation through Cdh16.
Title: Pax8 controls thyroid follicular polarity through cadherin-16.

the novel interplay between PAX8 and Neuropilin-2
Title: Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells.

The 5'-flanking region of the Wnt4 gene is responsive to Pax8. Pax8 modulates the expression of Wnt4 in thyroid cells.
Title: Pax8 modulates the expression of Wnt4 that is necessary for the maintenance of the epithelial phenotype of thyroid cells.

Pax8 is required for the survival of differentiated epithelial cells and its expression levels are able to modulate the proliferation rate of such cells.
Title: Pax8 has a critical role in epithelial cell survival and proliferation.

Distal regulation by Pax8 is supported by the interaction with chromatin remodeling factors such as CTCF and Sp1.
Title: Genome-wide analysis of Pax8 binding provides new insights into thyroid functions.

The following Pax8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pax8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa12106 NM_031141.2
Latest version!		 Rattus norvegicus paired box 8 (Pax8), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $223.30
$319.00
ORa25481 XM_008761610.2
Latest version!		 Rattus norvegicus paired box 8 (Pax8), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
ORa25481 XM_006233646.3
Latest version!		 Rattus norvegicus paired box 8 (Pax8), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
ORa25482 XM_008761611.2
Latest version!		 Rattus norvegicus paired box 8 (Pax8), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
ORa25483 XM_008761613.2
Latest version!		 Rattus norvegicus paired box 8 (Pax8), transcript variant X4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa12106
Clone ID Related Accession (Same CDS sequence) NM_031141.2
Accession Version NM_031141.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1374bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-02
Organism Rattus norvegicus(Norway rat)
Product paired box protein Pax-8
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081779.1. On Oct 5, 2005 this sequence version replaced NM_031141.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081779.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMN02642726 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCCTCACA ACTCGATCAG ATCCGGCCAC GGAGGGCTGA ATCAGTTAGG AGGGGCTTTT 
GTGAATGGCA GGCCTCTGCC AGAAGTTGTC CGGCAACGCA TTGTGGACTT GGCCCACCAG 
GGAGTGAGAC CCTGTGATAT CTCTCGCCAG CTTCGTGTCA GCCATGGCTG TGTAAGCAAG 
ATCCTTGGCA GGTACTACGA GACTGGCAGC ATCCGGCCTG GAGTGATAGG GGGCTCCAAG 
CCCAAGGTGG CCACCCCCAA GGTGGTGGAG AAGATAGGGG ACTACAAGCG GCAGAACCCT 
ACCATGTTTG CTTGGGAGAT CCGGGACCGG CTCTTGGCAG AAGGCGTTTG TGACAATGAC 
ACTGTGCCCA GTGTCAGCTC CATCAACAGA ATCATCCGGA CCAAAGTGCA GCAGCCATTC 
AACCTCCCCA TGGACAGCTG CGTGGCCACC AAATCTCTGA GCCCAGGACA CACACTGATC 
CCCAGCTCAG CTGTCACACC CCCAGAGTCA CCCCAGTCGG ATTCCTTGGG CTCTACCTAC 
TCTATCAACG GGCTCCTAGG AATTGCTCAG CCTGGCAGTG ACAACAAGAG AAAGATGGAT 
GATAGTGACC AGGACAGTTG TCGACTGAGC ATCGATTCCC AGAGCAGCAG TAGTGGTCCT 
CGAAAGCATC TTCGTACAGA CACCTTCGGG CAGCACCACC TCGAGCCGCT CGAGTGCCCG 
TTTGAGCGGC AGCATTACCC GGAGGCCTAT GCCTCCCCCA GCCACACCAA AGGCGAGCAG 
GGGCTATACC CACTGCCCTT ACTCAACAGT ACCCTGGATG ACGGAAAGGC CACCCTGACA 
CCTTCCAATA CACCTCTGGG ACGCAACCTC TCAACTCACC AGACCTACCC TGTGGTGGCA 
GATCCTCATT CACCCTACGC CATAAAGCAG GAAACCCCAG AGCTCTCCAG TTCTAGCTCC 
ACCCCTTCCT CTTTATCTAG CTCCGCCTTT TTGGATCTGC AGCAAGTCGG CTCTGGGGGC 
CCAGCAGGTG CCTCGGTCCC ACCCTTCAAT GCCTTTTCCC ATGCTGCCTC CGTGTATGGG 
CAGTTCACGG GCCAGGCCCT CCTCTCAGGG CGAGAGATGG TGGGGCCCAC GCTGCCTGGA 
TACCCACCCC ACATCCCCAC CAGTGGACAG GGCAGCTATG CCTCTTCCGC TATTGCAGGC 
ATGGTGGCAG GAAGTGAGTA TTCTGGCAAT GCCTACAGCC ACACCCCGTA CGCCTCCTAC 
AGTGAGGCCT GGCGCTTCCC CAACTCCAGC CTGCTGAGTT CCCCATATTA TTACAGCTCT 
ACAACAAGGC CAAGCGCACC GCCCACCTCT GCCACGGCCT TTGACCATCT GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_112403.2
CDS166..1539
Translation

Target ORF information:

RefSeq Version NM_031141.2
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus paired box 8 (Pax8), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_031141.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCCTCACA ACTCGATCAG ATCCGGCCAC GGAGGGCTGA ATCAGTTAGG AGGGGCTTTT 
GTGAATGGCA GGCCTCTGCC AGAAGTTGTC CGGCAACGCA TTGTGGACTT GGCCCACCAG 
GGAGTGAGAC CCTGTGATAT CTCTCGCCAG CTTCGTGTCA GCCATGGCTG TGTAAGCAAG 
ATCCTTGGCA GGTACTACGA GACTGGCAGC ATCCGGCCTG GAGTGATAGG GGGCTCCAAG 
CCCAAGGTGG CCACCCCCAA GGTGGTGGAG AAGATAGGGG ACTACAAGCG GCAGAACCCT 
ACCATGTTTG CTTGGGAGAT CCGGGACCGG CTCTTGGCAG AAGGCGTTTG TGACAATGAC 
ACTGTGCCCA GTGTCAGCTC CATCAACAGA ATCATCCGGA CCAAAGTGCA GCAGCCATTC 
AACCTCCCCA TGGACAGCTG CGTGGCCACC AAATCTCTGA GCCCAGGACA CACACTGATC 
CCCAGCTCAG CTGTCACACC CCCAGAGTCA CCCCAGTCGG ATTCCTTGGG CTCTACCTAC 
TCTATCAACG GGCTCCTAGG AATTGCTCAG CCTGGCAGTG ACAACAAGAG AAAGATGGAT 
GATAGTGACC AGGACAGTTG TCGACTGAGC ATCGATTCCC AGAGCAGCAG TAGTGGTCCT 
CGAAAGCATC TTCGTACAGA CACCTTCGGG CAGCACCACC TCGAGCCGCT CGAGTGCCCG 
TTTGAGCGGC AGCATTACCC GGAGGCCTAT GCCTCCCCCA GCCACACCAA AGGCGAGCAG 
GGGCTATACC CACTGCCCTT ACTCAACAGT ACCCTGGATG ACGGAAAGGC CACCCTGACA 
CCTTCCAATA CACCTCTGGG ACGCAACCTC TCAACTCACC AGACCTACCC TGTGGTGGCA 
GATCCTCATT CACCCTACGC CATAAAGCAG GAAACCCCAG AGCTCTCCAG TTCTAGCTCC 
ACCCCTTCCT CTTTATCTAG CTCCGCCTTT TTGGATCTGC AGCAAGTCGG CTCTGGGGGC 
CCAGCAGGTG CCTCGGTCCC ACCCTTCAAT GCCTTTTCCC ATGCTGCCTC CGTGTATGGG 
CAGTTCACGG GCCAGGCCCT CCTCTCAGGG CGAGAGATGG TGGGGCCCAC GCTGCCTGGA 
TACCCACCCC ACATCCCCAC CAGTGGACAG GGCAGCTATG CCTCTTCCGC TATTGCAGGC 
ATGGTGGCAG GAAGTGAGTA TTCTGGCAAT GCCTACAGCC ACACCCCGTA CGCCTCCTAC 
AGTGAGGCCT GGCGCTTCCC CAACTCCAGC CTGCTGAGTT CCCCATATTA TTACAGCTCT 
ACAACAAGGC CAAGCGCACC GCCCACCTCT GCCACGGCCT TTGACCATCT GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa25481
Clone ID Related Accession (Same CDS sequence) XM_008761610.2 , XM_006233646.3
Accession Version XM_008761610.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1377bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product paired box protein Pax-8 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008761610.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCCTCACA ACTCGATCAG ATCCGGCCAC GGAGGGCTGA ATCAGTTAGG AGGGGCTTTT 
GTGAATGGCA GGCCTCTGCC AGAAGTTGTC CGGCAACGCA TTGTGGACTT GGCCCACCAG 
GGAGTGAGAC CCTGTGATAT CTCTCGCCAG CTTCGTGTCA GCCATGGCTG TGTAAGCAAG 
ATCCTTGGCA GTAGGTACTA CGAGACTGGC AGCATCCGGC CTGGAGTGAT AGGGGGCTCC 
AAGCCCAAGG TGGCCACCCC CAAGGTGGTG GAGAAGATAG GGGACTACAA GCGGCAGAAC 
CCTACCATGT TTGCTTGGGA GATCCGGGAC CGGCTCTTGG CAGAAGGCGT TTGTGACAAT 
GACACTGTGC CCAGTGTCAG CTCCATCAAC AGAATCATCC GGACCAAAGT GCAGCAGCCA 
TTCAACCTCC CCATGGACAG CTGCGTGGCC ACCAAATCTC TGAGCCCAGG ACACACACTG 
ATCCCCAGCT CAGCTGTCAC ACCCCCAGAG TCACCCCAGT CGGATTCCTT GGGCTCTACC 
TACTCTATCA ACGGGCTCCT AGGAATTGCT CAGCCTGGCA GTGACAACAA GAGAAAGATG 
GATGATAGTG ACCAGGACAG TTGTCGACTG AGCATCGATT CCCAGAGCAG CAGTAGTGGT 
CCTCGAAAGC ATCTTCGTAC AGACACCTTC GGGCAGCACC ACCTCGAGCC GCTCGAGTGC 
CCGTTTGAGC GGCAGCATTA CCCGGAGGCC TATGCCTCCC CCAGCCACAC CAAAGGCGAG 
CAGGGGCTAT ACCCACTGCC CTTACTCAAC AGTACCCTGG ATGACGGAAA GGCCACCCTG 
ACACCTTCCA ATACACCTCT GGGACGCAAC CTCTCAACTC ACCAGACCTA CCCTGTGGTG 
GCAGATCCTC ATTCACCCTA CGCCATAAAG CAGGAAACCC CAGAGCTCTC CAGTTCTAGC 
TCCACCCCTT CCTCTTTATC TAGCTCCGCC TTTTTGGATC TGCAGCAAGT CGGCTCTGGG 
GGCCCAGCAG GTGCCTCGGT CCCACCCTTC AATGCCTTTT CCCATGCTGC CTCCGTGTAT 
GGGCAGTTCA CGGGCCAGGC CCTCCTCTCA GGGCGAGAGA TGGTGGGGCC CACGCTGCCT 
GGATACCCAC CCCACATCCC CACCAGTGGA CAGGGCAGCT ATGCCTCTTC CGCTATTGCA 
GGCATGGTGG CAGGAAGTGA GTATTCTGGC AATGCCTACA GCCACACCCC GTACGCCTCC 
TACAGTGAGG CCTGGCGCTT CCCCAACTCC AGCCTGCTGA GTTCCCCATA TTATTACAGC 
TCTACAACAA GGCCAAGCGC ACCGCCCACC TCTGCCACGG CCTTTGACCA TCTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_008759832.1
CDS1595..2971
Translation

Target ORF information:

RefSeq Version XM_008761610.2
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus paired box 8 (Pax8), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_008761610.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCCTCACA ACTCGATCAG ATCCGGCCAC GGAGGGCTGA ATCAGTTAGG AGGGGCTTTT 
GTGAATGGCA GGCCTCTGCC AGAAGTTGTC CGGCAACGCA TTGTGGACTT GGCCCACCAG 
GGAGTGAGAC CCTGTGATAT CTCTCGCCAG CTTCGTGTCA GCCATGGCTG TGTAAGCAAG 
ATCCTTGGCA GTAGGTACTA CGAGACTGGC AGCATCCGGC CTGGAGTGAT AGGGGGCTCC 
AAGCCCAAGG TGGCCACCCC CAAGGTGGTG GAGAAGATAG GGGACTACAA GCGGCAGAAC 
CCTACCATGT TTGCTTGGGA GATCCGGGAC CGGCTCTTGG CAGAAGGCGT TTGTGACAAT 
GACACTGTGC CCAGTGTCAG CTCCATCAAC AGAATCATCC GGACCAAAGT GCAGCAGCCA 
TTCAACCTCC CCATGGACAG CTGCGTGGCC ACCAAATCTC TGAGCCCAGG ACACACACTG 
ATCCCCAGCT CAGCTGTCAC ACCCCCAGAG TCACCCCAGT CGGATTCCTT GGGCTCTACC 
TACTCTATCA ACGGGCTCCT AGGAATTGCT CAGCCTGGCA GTGACAACAA GAGAAAGATG 
GATGATAGTG ACCAGGACAG TTGTCGACTG AGCATCGATT CCCAGAGCAG CAGTAGTGGT 
CCTCGAAAGC ATCTTCGTAC AGACACCTTC GGGCAGCACC ACCTCGAGCC GCTCGAGTGC 
CCGTTTGAGC GGCAGCATTA CCCGGAGGCC TATGCCTCCC CCAGCCACAC CAAAGGCGAG 
CAGGGGCTAT ACCCACTGCC CTTACTCAAC AGTACCCTGG ATGACGGAAA GGCCACCCTG 
ACACCTTCCA ATACACCTCT GGGACGCAAC CTCTCAACTC ACCAGACCTA CCCTGTGGTG 
GCAGATCCTC ATTCACCCTA CGCCATAAAG CAGGAAACCC CAGAGCTCTC CAGTTCTAGC 
TCCACCCCTT CCTCTTTATC TAGCTCCGCC TTTTTGGATC TGCAGCAAGT CGGCTCTGGG 
GGCCCAGCAG GTGCCTCGGT CCCACCCTTC AATGCCTTTT CCCATGCTGC CTCCGTGTAT 
GGGCAGTTCA CGGGCCAGGC CCTCCTCTCA GGGCGAGAGA TGGTGGGGCC CACGCTGCCT 
GGATACCCAC CCCACATCCC CACCAGTGGA CAGGGCAGCT ATGCCTCTTC CGCTATTGCA 
GGCATGGTGG CAGGAAGTGA GTATTCTGGC AATGCCTACA GCCACACCCC GTACGCCTCC 
TACAGTGAGG CCTGGCGCTT CCCCAACTCC AGCCTGCTGA GTTCCCCATA TTATTACAGC 
TCTACAACAA GGCCAAGCGC ACCGCCCACC TCTGCCACGG CCTTTGACCA TCTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa25481
Clone ID Related Accession (Same CDS sequence) XM_008761610.2 , XM_006233646.3
Accession Version XM_006233646.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1377bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product paired box protein Pax-8 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006233646.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCCTCACA ACTCGATCAG ATCCGGCCAC GGAGGGCTGA ATCAGTTAGG AGGGGCTTTT 
GTGAATGGCA GGCCTCTGCC AGAAGTTGTC CGGCAACGCA TTGTGGACTT GGCCCACCAG 
GGAGTGAGAC CCTGTGATAT CTCTCGCCAG CTTCGTGTCA GCCATGGCTG TGTAAGCAAG 
ATCCTTGGCA GTAGGTACTA CGAGACTGGC AGCATCCGGC CTGGAGTGAT AGGGGGCTCC 
AAGCCCAAGG TGGCCACCCC CAAGGTGGTG GAGAAGATAG GGGACTACAA GCGGCAGAAC 
CCTACCATGT TTGCTTGGGA GATCCGGGAC CGGCTCTTGG CAGAAGGCGT TTGTGACAAT 
GACACTGTGC CCAGTGTCAG CTCCATCAAC AGAATCATCC GGACCAAAGT GCAGCAGCCA 
TTCAACCTCC CCATGGACAG CTGCGTGGCC ACCAAATCTC TGAGCCCAGG ACACACACTG 
ATCCCCAGCT CAGCTGTCAC ACCCCCAGAG TCACCCCAGT CGGATTCCTT GGGCTCTACC 
TACTCTATCA ACGGGCTCCT AGGAATTGCT CAGCCTGGCA GTGACAACAA GAGAAAGATG 
GATGATAGTG ACCAGGACAG TTGTCGACTG AGCATCGATT CCCAGAGCAG CAGTAGTGGT 
CCTCGAAAGC ATCTTCGTAC AGACACCTTC GGGCAGCACC ACCTCGAGCC GCTCGAGTGC 
CCGTTTGAGC GGCAGCATTA CCCGGAGGCC TATGCCTCCC CCAGCCACAC CAAAGGCGAG 
CAGGGGCTAT ACCCACTGCC CTTACTCAAC AGTACCCTGG ATGACGGAAA GGCCACCCTG 
ACACCTTCCA ATACACCTCT GGGACGCAAC CTCTCAACTC ACCAGACCTA CCCTGTGGTG 
GCAGATCCTC ATTCACCCTA CGCCATAAAG CAGGAAACCC CAGAGCTCTC CAGTTCTAGC 
TCCACCCCTT CCTCTTTATC TAGCTCCGCC TTTTTGGATC TGCAGCAAGT CGGCTCTGGG 
GGCCCAGCAG GTGCCTCGGT CCCACCCTTC AATGCCTTTT CCCATGCTGC CTCCGTGTAT 
GGGCAGTTCA CGGGCCAGGC CCTCCTCTCA GGGCGAGAGA TGGTGGGGCC CACGCTGCCT 
GGATACCCAC CCCACATCCC CACCAGTGGA CAGGGCAGCT ATGCCTCTTC CGCTATTGCA 
GGCATGGTGG CAGGAAGTGA GTATTCTGGC AATGCCTACA GCCACACCCC GTACGCCTCC 
TACAGTGAGG CCTGGCGCTT CCCCAACTCC AGCCTGCTGA GTTCCCCATA TTATTACAGC 
TCTACAACAA GGCCAAGCGC ACCGCCCACC TCTGCCACGG CCTTTGACCA TCTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006233708.1
CDS1259..2635
Translation

Target ORF information:

RefSeq Version XM_006233646.3
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus paired box 8 (Pax8), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006233646.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCCTCACA ACTCGATCAG ATCCGGCCAC GGAGGGCTGA ATCAGTTAGG AGGGGCTTTT 
GTGAATGGCA GGCCTCTGCC AGAAGTTGTC CGGCAACGCA TTGTGGACTT GGCCCACCAG 
GGAGTGAGAC CCTGTGATAT CTCTCGCCAG CTTCGTGTCA GCCATGGCTG TGTAAGCAAG 
ATCCTTGGCA GTAGGTACTA CGAGACTGGC AGCATCCGGC CTGGAGTGAT AGGGGGCTCC 
AAGCCCAAGG TGGCCACCCC CAAGGTGGTG GAGAAGATAG GGGACTACAA GCGGCAGAAC 
CCTACCATGT TTGCTTGGGA GATCCGGGAC CGGCTCTTGG CAGAAGGCGT TTGTGACAAT 
GACACTGTGC CCAGTGTCAG CTCCATCAAC AGAATCATCC GGACCAAAGT GCAGCAGCCA 
TTCAACCTCC CCATGGACAG CTGCGTGGCC ACCAAATCTC TGAGCCCAGG ACACACACTG 
ATCCCCAGCT CAGCTGTCAC ACCCCCAGAG TCACCCCAGT CGGATTCCTT GGGCTCTACC 
TACTCTATCA ACGGGCTCCT AGGAATTGCT CAGCCTGGCA GTGACAACAA GAGAAAGATG 
GATGATAGTG ACCAGGACAG TTGTCGACTG AGCATCGATT CCCAGAGCAG CAGTAGTGGT 
CCTCGAAAGC ATCTTCGTAC AGACACCTTC GGGCAGCACC ACCTCGAGCC GCTCGAGTGC 
CCGTTTGAGC GGCAGCATTA CCCGGAGGCC TATGCCTCCC CCAGCCACAC CAAAGGCGAG 
CAGGGGCTAT ACCCACTGCC CTTACTCAAC AGTACCCTGG ATGACGGAAA GGCCACCCTG 
ACACCTTCCA ATACACCTCT GGGACGCAAC CTCTCAACTC ACCAGACCTA CCCTGTGGTG 
GCAGATCCTC ATTCACCCTA CGCCATAAAG CAGGAAACCC CAGAGCTCTC CAGTTCTAGC 
TCCACCCCTT CCTCTTTATC TAGCTCCGCC TTTTTGGATC TGCAGCAAGT CGGCTCTGGG 
GGCCCAGCAG GTGCCTCGGT CCCACCCTTC AATGCCTTTT CCCATGCTGC CTCCGTGTAT 
GGGCAGTTCA CGGGCCAGGC CCTCCTCTCA GGGCGAGAGA TGGTGGGGCC CACGCTGCCT 
GGATACCCAC CCCACATCCC CACCAGTGGA CAGGGCAGCT ATGCCTCTTC CGCTATTGCA 
GGCATGGTGG CAGGAAGTGA GTATTCTGGC AATGCCTACA GCCACACCCC GTACGCCTCC 
TACAGTGAGG CCTGGCGCTT CCCCAACTCC AGCCTGCTGA GTTCCCCATA TTATTACAGC 
TCTACAACAA GGCCAAGCGC ACCGCCCACC TCTGCCACGG CCTTTGACCA TCTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa25482
Clone ID Related Accession (Same CDS sequence) XM_008761611.2
Accession Version XM_008761611.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1170bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product paired box protein Pax-8 isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008761611.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCCTCACA ACTCGATCAG ATCCGGCCAC GGAGGGCTGA ATCAGTTAGG AGGGGCTTTT 
GTGAATGGCA GGCCTCTGCC AGAAGTTGTC CGGCAACGCA TTGTGGACTT GGCCCACCAG 
GGAGTGAGAC CCTGTGATAT CTCTCGCCAG CTTCGTGTCA GCCATGGCTG TGTAAGCAAG 
ATCCTTGGCA GTAGGTACTA CGAGACTGGC AGCATCCGGC CTGGAGTGAT AGGGGGCTCC 
AAGCCCAAGG TGGCCACCCC CAAGGTGGTG GAGAAGATAG GGGACTACAA GCGGCAGAAC 
CCTACCATGT TTGCTTGGGA GATCCGGGAC CGGCTCTTGG CAGAAGGCGT TTGTGACAAT 
GACACTGTGC CCAGTGTCAG CTCCATCAAC AGAATCATCC GGACCAAAGT GCAGCAGCCA 
TTCAACCTCC CCATGGACAG CTGCGTGGCC ACCAAATCTC TGAGCCCAGG ACACACACTG 
ATCCCCAGCT CAGCTGTCAC ACCCCCAGAG TCACCCCAGT CGGATTCCTT GGGCTCTACC 
TACTCTATCA ACGGGCTCCT AGGAATTGCT CAGCCTGGCA GTGACAACAA GAGAAAGATG 
GATGATAGTG ACCAGGACAG TTGTCGACTG AGCATCGATT CCCAGAGCAG CAGTAGTGGT 
CCTCGAAAGC ATCTTCGTAC AGACACCTTC GGGCAGCACC ACCTCGAGCC GCTCGAGTGC 
CCGTTTGAGC GGCAGCATTA CCCGGAGGCC TATGCCTCCC CCAGCCACAC CAAAGGCGAG 
CAGGGGCTAT ACCCACTGCC CTTACTCAAC AGTACCCTGG ATGACGGAAA GGCCACCCTG 
ACACCTTCCA ATACACCTCT GGGACGCAAC CTCTCAACTC ACCAGACCTA CCCTGTGGTG 
GCAGGGCGAG AGATGGTGGG GCCCACGCTG CCTGGATACC CACCCCACAT CCCCACCAGT 
GGACAGGGCA GCTATGCCTC TTCCGCTATT GCAGGCATGG TGGCAGGAAG TGAGTATTCT 
GGCAATGCCT ACAGCCACAC CCCGTACGCC TCCTACAGTG AGGCCTGGCG CTTCCCCAAC 
TCCAGCCTGC TGAGTTCCCC ATATTATTAC AGCTCTACAA CAAGGCCAAG CGCACCGCCC 
ACCTCTGCCA CGGCCTTTGA CCATCTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_008759833.1
CDS1596..2765
Translation

Target ORF information:

RefSeq Version XM_008761611.2
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus paired box 8 (Pax8), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_008761611.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCCTCACA ACTCGATCAG ATCCGGCCAC GGAGGGCTGA ATCAGTTAGG AGGGGCTTTT 
GTGAATGGCA GGCCTCTGCC AGAAGTTGTC CGGCAACGCA TTGTGGACTT GGCCCACCAG 
GGAGTGAGAC CCTGTGATAT CTCTCGCCAG CTTCGTGTCA GCCATGGCTG TGTAAGCAAG 
ATCCTTGGCA GTAGGTACTA CGAGACTGGC AGCATCCGGC CTGGAGTGAT AGGGGGCTCC 
AAGCCCAAGG TGGCCACCCC CAAGGTGGTG GAGAAGATAG GGGACTACAA GCGGCAGAAC 
CCTACCATGT TTGCTTGGGA GATCCGGGAC CGGCTCTTGG CAGAAGGCGT TTGTGACAAT 
GACACTGTGC CCAGTGTCAG CTCCATCAAC AGAATCATCC GGACCAAAGT GCAGCAGCCA 
TTCAACCTCC CCATGGACAG CTGCGTGGCC ACCAAATCTC TGAGCCCAGG ACACACACTG 
ATCCCCAGCT CAGCTGTCAC ACCCCCAGAG TCACCCCAGT CGGATTCCTT GGGCTCTACC 
TACTCTATCA ACGGGCTCCT AGGAATTGCT CAGCCTGGCA GTGACAACAA GAGAAAGATG 
GATGATAGTG ACCAGGACAG TTGTCGACTG AGCATCGATT CCCAGAGCAG CAGTAGTGGT 
CCTCGAAAGC ATCTTCGTAC AGACACCTTC GGGCAGCACC ACCTCGAGCC GCTCGAGTGC 
CCGTTTGAGC GGCAGCATTA CCCGGAGGCC TATGCCTCCC CCAGCCACAC CAAAGGCGAG 
CAGGGGCTAT ACCCACTGCC CTTACTCAAC AGTACCCTGG ATGACGGAAA GGCCACCCTG 
ACACCTTCCA ATACACCTCT GGGACGCAAC CTCTCAACTC ACCAGACCTA CCCTGTGGTG 
GCAGGGCGAG AGATGGTGGG GCCCACGCTG CCTGGATACC CACCCCACAT CCCCACCAGT 
GGACAGGGCA GCTATGCCTC TTCCGCTATT GCAGGCATGG TGGCAGGAAG TGAGTATTCT 
GGCAATGCCT ACAGCCACAC CCCGTACGCC TCCTACAGTG AGGCCTGGCG CTTCCCCAAC 
TCCAGCCTGC TGAGTTCCCC ATATTATTAC AGCTCTACAA CAAGGCCAAG CGCACCGCCC 
ACCTCTGCCA CGGCCTTTGA CCATCTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa25483
Clone ID Related Accession (Same CDS sequence) XM_008761613.2
Accession Version XM_008761613.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1167bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product paired box protein Pax-8 isoform X3
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008761613.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCCTCACA ACTCGATCAG ATCCGGCCAC GGAGGGCTGA ATCAGTTAGG AGGGGCTTTT 
GTGAATGGCA GGCCTCTGCC AGAAGTTGTC CGGCAACGCA TTGTGGACTT GGCCCACCAG 
GGAGTGAGAC CCTGTGATAT CTCTCGCCAG CTTCGTGTCA GCCATGGCTG TGTAAGCAAG 
ATCCTTGGCA GGTACTACGA GACTGGCAGC ATCCGGCCTG GAGTGATAGG GGGCTCCAAG 
CCCAAGGTGG CCACCCCCAA GGTGGTGGAG AAGATAGGGG ACTACAAGCG GCAGAACCCT 
ACCATGTTTG CTTGGGAGAT CCGGGACCGG CTCTTGGCAG AAGGCGTTTG TGACAATGAC 
ACTGTGCCCA GTGTCAGCTC CATCAACAGA ATCATCCGGA CCAAAGTGCA GCAGCCATTC 
AACCTCCCCA TGGACAGCTG CGTGGCCACC AAATCTCTGA GCCCAGGACA CACACTGATC 
CCCAGCTCAG CTGTCACACC CCCAGAGTCA CCCCAGTCGG ATTCCTTGGG CTCTACCTAC 
TCTATCAACG GGCTCCTAGG AATTGCTCAG CCTGGCAGTG ACAACAAGAG AAAGATGGAT 
GATAGTGACC AGGACAGTTG TCGACTGAGC ATCGATTCCC AGAGCAGCAG TAGTGGTCCT 
CGAAAGCATC TTCGTACAGA CACCTTCGGG CAGCACCACC TCGAGCCGCT CGAGTGCCCG 
TTTGAGCGGC AGCATTACCC GGAGGCCTAT GCCTCCCCCA GCCACACCAA AGGCGAGCAG 
GGGCTATACC CACTGCCCTT ACTCAACAGT ACCCTGGATG ACGGAAAGGC CACCCTGACA 
CCTTCCAATA CACCTCTGGG ACGCAACCTC TCAACTCACC AGACCTACCC TGTGGTGGCA 
GGGCGAGAGA TGGTGGGGCC CACGCTGCCT GGATACCCAC CCCACATCCC CACCAGTGGA 
CAGGGCAGCT ATGCCTCTTC CGCTATTGCA GGCATGGTGG CAGGAAGTGA GTATTCTGGC 
AATGCCTACA GCCACACCCC GTACGCCTCC TACAGTGAGG CCTGGCGCTT CCCCAACTCC 
AGCCTGCTGA GTTCCCCATA TTATTACAGC TCTACAACAA GGCCAAGCGC ACCGCCCACC 
TCTGCCACGG CCTTTGACCA TCTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_008759835.1
CDS504..1670
Translation

Target ORF information:

RefSeq Version XM_008761613.2
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus paired box 8 (Pax8), transcript variant X4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_008761613.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCCTCACA ACTCGATCAG ATCCGGCCAC GGAGGGCTGA ATCAGTTAGG AGGGGCTTTT 
GTGAATGGCA GGCCTCTGCC AGAAGTTGTC CGGCAACGCA TTGTGGACTT GGCCCACCAG 
GGAGTGAGAC CCTGTGATAT CTCTCGCCAG CTTCGTGTCA GCCATGGCTG TGTAAGCAAG 
ATCCTTGGCA GGTACTACGA GACTGGCAGC ATCCGGCCTG GAGTGATAGG GGGCTCCAAG 
CCCAAGGTGG CCACCCCCAA GGTGGTGGAG AAGATAGGGG ACTACAAGCG GCAGAACCCT 
ACCATGTTTG CTTGGGAGAT CCGGGACCGG CTCTTGGCAG AAGGCGTTTG TGACAATGAC 
ACTGTGCCCA GTGTCAGCTC CATCAACAGA ATCATCCGGA CCAAAGTGCA GCAGCCATTC 
AACCTCCCCA TGGACAGCTG CGTGGCCACC AAATCTCTGA GCCCAGGACA CACACTGATC 
CCCAGCTCAG CTGTCACACC CCCAGAGTCA CCCCAGTCGG ATTCCTTGGG CTCTACCTAC 
TCTATCAACG GGCTCCTAGG AATTGCTCAG CCTGGCAGTG ACAACAAGAG AAAGATGGAT 
GATAGTGACC AGGACAGTTG TCGACTGAGC ATCGATTCCC AGAGCAGCAG TAGTGGTCCT 
CGAAAGCATC TTCGTACAGA CACCTTCGGG CAGCACCACC TCGAGCCGCT CGAGTGCCCG 
TTTGAGCGGC AGCATTACCC GGAGGCCTAT GCCTCCCCCA GCCACACCAA AGGCGAGCAG 
GGGCTATACC CACTGCCCTT ACTCAACAGT ACCCTGGATG ACGGAAAGGC CACCCTGACA 
CCTTCCAATA CACCTCTGGG ACGCAACCTC TCAACTCACC AGACCTACCC TGTGGTGGCA 
GGGCGAGAGA TGGTGGGGCC CACGCTGCCT GGATACCCAC CCCACATCCC CACCAGTGGA 
CAGGGCAGCT ATGCCTCTTC CGCTATTGCA GGCATGGTGG CAGGAAGTGA GTATTCTGGC 
AATGCCTACA GCCACACCCC GTACGCCTCC TACAGTGAGG CCTGGCGCTT CCCCAACTCC 
AGCCTGCTGA GTTCCCCATA TTATTACAGC TCTACAACAA GGCCAAGCGC ACCGCCCACC 
TCTGCCACGG CCTTTGACCA TCTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Pax8 controls thyroid follicular polarity through cadherin-16.
Journal of cell science130(1)219-231(2017 01)
Koumarianou P,Gom?z-L?pez G,Santisteban P


book

Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells.
PloS one10(6)e0128315(2015)
Lucci V,Di Palma T,Zannini M


book

Pax8 modulates the expression of Wnt4 that is necessary for the maintenance of the epithelial phenotype of thyroid cells.
BMC molecular biology1521(2014 Sep)
Filippone MG,Di Palma T,Lucci V,Zannini M


book

Pax8 has a critical role in epithelial cell survival and proliferation.
Cell death & disease4e729(2013 Jul)
Di Palma T,Filippone MG,Pierantoni GM,Fusco A,Soddu S,Zannini M


book

Genome-wide analysis of Pax8 binding provides new insights into thyroid functions.
BMC genomics13147(2012 Apr)
Ruiz-Llorente S,Carrillo Santa de Pau E,Sastre-Perona A,Montero-Conde C,G?mez-L?pez G,Fagin JA,Valencia A,Pisano DG,Santisteban P