Aifm1 cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Aifm1 |
| Entrez Gene ID | 83533 |
| Full Name | apoptosis inducing factor, mitochondria associated 1 |
| Synonyms | Aif,Pdcd8 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | may facilitate apoptotic chromatin condensation and DNA degradation [RGD, Feb 2006]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_031356.1 | NP_112646.1 | apoptosis-inducing factor 1, mitochondrial precursor |
| Bos taurus (cattle) | AIFM1 | NP_001179913.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP008044 | XP_317418.4 |
| Caenorhabditis elegans (roundworm) | wah-1 | NP_499564.2 |
| Canis lupus familiaris (dog) | AIFM1 | XP_538170.2 |
| Mus musculus (house mouse) | Aifm1 | NP_036149.1 |
| Gallus gallus (chicken) | AIFM1 | NP_001007491.1 |
| Drosophila melanogaster (fruit fly) | AIF | NP_001259907.1 |
| Rattus norvegicus (Norway rat) | Aifm1 | NP_112646.1 |
| Homo sapiens (human) | AIFM1 | NP_004199.1 |
| Danio rerio (zebrafish) | aifm1 | NP_956396.2 |
| Pan troglodytes (chimpanzee) | AIFM1 | XP_003317723.1 |
| AIFM1 | XP_001092025.1 | |
| Xenopus tropicalis (tropical clawed frog) | aifm1 | NP_001017244.1 |
Related articles in PubMed
Drp1 mediates compression-induced programmed necrosis of rat nucleus pulposus cells by promoting mitochondrial translocation of p53 and nuclear translocation of AIF.
Lin H, Zhao L, Ma X, Wang BC, Deng XY, Cui M, Chen SF, Shao ZW
Biochemical and biophysical research communications487(1)181-188(2017 May)
Apoptosis Inducing Factor Is Involved in Stretch-Induced Apoptosis of Myoblast via a Caspase-9 Independent Pathway.
Wang F, Wei ZL, Sun XR, Zhang Q, Zhang CX, Jiang WX, Yan X, Liu JN, Yuan X
Journal of cellular biochemistry118(4)829-838(2017 Apr)
Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia-ischemia.
Yang X, Cheng J, Gao Y, Ding J, Ni X
Neuroscience34674-80(2017 Mar)
RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF.
Xu Y, Wang J, Song X, Qu L, Wei R, He F, Wang K, Luo B
Scientific reports629362(2016 Jul)
PARP-1-modulated AIF translocation is involved in streptomycin-induced cochlear hair cell death.
Song Y, Fan Z, Bai X, Liu W, Han Y, Xu L, Wang M, Li J, Zheng Q, Zhang D, Wang H
Acta oto-laryngologica136(6)545-50(2016 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These data indicates that Drp1 mediates compression-induced programmed necrosis of NP cells by promoting mitochondrial translocation of p53 and nuclear translocation of AIF.
Title: Drp1 mediates compression-induced programmed necrosis of rat nucleus pulposus cells by promoting mitochondrial translocation of p53 and nuclear translocation of AIF.
investigated the mechanobiological roles of caspase-9 and Apoptosis Inducing Factor (AIF), two important components in mitochondrial pathway, in stretch-induced apoptosis of myoblasts
Title: Apoptosis Inducing Factor Is Involved in Stretch-Induced Apoptosis of Myoblast via a Caspase-9 Independent Pathway.
Results suggest that apoptosis-inducing factor nuclear translocation and neuronal cell death are associated with Iduna loss after severe hypoxic-ischemic in the immature brain.
Title: Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia-ischemia.
involved in streptomycin ototoxicity by translocation from mitochondria to cytosol and nucleus of cochlear hair cells
Title: PARP-1-modulated AIF translocation is involved in streptomycin-induced cochlear hair cell death.
Data indicate that mitochondrial apoptosis-inducing factor (AIF) silencing prevents doxorubicin toxicity on cardiomyoblasts.
Title: Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts.
The following Aifm1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aifm1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa12427 | |
| Clone ID Related Accession (Same CDS sequence) | NM_031356.1 | |
| Accession Version | NM_031356.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1839bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-18 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | apoptosis-inducing factor 1, mitochondrial precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB041723.1. Sequence Note: This sequence has been modified as follows: removed 16 bp suspected to be vector contamination from the 5' end. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB041723.1, AF375656.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## | |
1 | ATGTTCCGGT GTGGAGGCCT GGCGGGTGCT TTCAAGCAGA AACTGGTGCC CTTGGTGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_112646.1 |
| CDS | 75..1913 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_031356.1 |
ORF Insert Sequence:
1 | ATGTTCCGGT GTGGAGGCCT GGCGGGTGCT TTCAAGCAGA AACTGGTGCC CTTGGTGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Drp1 mediates compression-induced programmed necrosis of rat nucleus pulposus cells by promoting mitochondrial translocation of p53 and nuclear translocation of AIF. |
|
Apoptosis Inducing Factor Is Involved in Stretch-Induced Apoptosis of Myoblast via a Caspase-9 Independent Pathway. |
|
Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia-ischemia. |
|
RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF. |
|
PARP-1-modulated AIF translocation is involved in streptomycin-induced cochlear hair cell death. |