selenop1 cDNA ORF clone, Xenopus tropicalis(tropical clawed frog)
| Gene Symbol | selenop1 |
| Entrez Gene ID | 100379942 |
| Full Name | selenoprotein P1 |
| Synonyms | selenop,sepp1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Xenopus tropicalis(tropical clawed frog) |
| Summary | This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma in mammals. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (18 in Xenopus tropicalis), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. [provided by RefSeq, Feb 2017]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001199884.1 | NP_001186813.1 | selenoprotein P precursor |
| Mus musculus (house mouse) | Sepp1 | NP_001036078.1 |
| Rattus norvegicus (Norway rat) | Sepp1 | NP_001077380.1 |
| Homo sapiens (human) | SEPP1 | NP_005401.3 |
| Gallus gallus (chicken) | SEPP1 | NP_001026780.2 |
| Bos taurus (cattle) | SEPP1 | NP_776884.2 |
| SEPP1 | NP_001152962.1 | |
| Canis lupus familiaris (dog) | SEPP1 | NP_001108590.1 |
| Danio rerio (zebrafish) | sepp1a | NP_840082.2 |
| Pan troglodytes (chimpanzee) | SEPP1 | NP_001108587.1 |
| Xenopus tropicalis (tropical clawed frog) | sepp1 | NP_001186813.1 |
Related articles in PubMed
Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)
Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative.
Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW, Richardson P
Developmental dynamics : an official publication of the American Association of Anatomists225(4)384-91(2002 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following selenop1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the selenop1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OXa25545 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001199884.1 | |
| Accession Version | NM_001199884.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1209bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-21 | |
| Organism | Xenopus tropicalis(tropical clawed frog) | |
| Product | selenoprotein P precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DN069392.1 and BC161127.1. On Dec 27, 2010 this sequence version replaced XM_002933046.1. ##Evidence-Data-START## Transcript exon combination :: BC161127.1, EL653709.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00028290, SAMD00028291 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGTGGAAGG GCTTTGCTCT TGCCCTGGCT CTTTGCCTTC TCCCTTGGGG AGGGGCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001186813.1 |
| CDS | 158..1366 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001199884.1 |
ORF Insert Sequence:
1 | ATGTGGAAGG GCTTTGCTCT TGCCCTGGCT CTTTGCCTTC TCCCTTGGGG AGGGGCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Selenoprotein Gene Nomenclature. |
|
Composition and evolution of the vertebrate and mammalian selenoproteomes. |
|
Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. |