GenTitan™ Oligo Pools

NGS Target Enrichment

Next-generation sequencing (NGS) target enrichment utilizing oligo pools has emerged as a transformative technique in genomics research. By custom designing pools of oligonucleotide probes complementary to specific genomic regions of interest, researchers can efficiently capture and amplify relevant DNA fragments for sequencing. This approach not only streamlines the sequencing process but also significantly reduces the cost and data burden.

• Advantages of using array-synthesized, double stranded DNA capture probes in NGS targeted sequencing^{Application Note}

Protein & Antibody Engineering

Mutant libraries are powerful, high-throughput tools for optimizing protein structure and function. However, traditional methods for library construction, including error-prone PCR or degenerate methods, suffer from limited control over codon usage and poor variant representation. Powered by our semiconductor-based oligo synthesis technology, our Precision Mutant Library service offers precise control over each synthesized variant. The result is a more diverse and fully covered mutant library with unbiased distribution.

• Assembly of precise mutant libraries using arrayed-synthesized oligos for protein optimization^{Application Note}

Library services we offer:

• Site-directed mutagenesis
• Scanning point mutation
• Randomized and degenerated
• Site saturation and saturation scanning mutagenesis
• Combinatorial mutagenesis

Gene Fragments

Gene Fragments offer a cost-effective, swift, and effective avenue for constructing the requisite genes in your research endeavors. These double-stranded DNA fragments of up to 1,800 base pairs in length, fulfilling the demands of easy gene construction or modification suitable for a variety of applications, including antibody development, CRISPR-mediated genome editing, and NGS controls. The GenTitan™ Gene Fragments Service leverages our exclusive complementary metal oxide semiconductor (CMOS) integrated circuits (IC), ensuring unmatched precision, accelerated delivery schedules, and exceptional cost-effectiveness.

DNA Data Storage

DNA data storage involves encoding digital information as DNA sequences, utilizing the four DNA bases (A, T, C, and G) to represent binary data (0s and 1s). These sequences can be later synthesized into DNA strands for storage. Oligo pools are used to generate these sequences efficiently and in parallel, allowing large amounts of data to be encoded using unique combinations of oligos.

GenTitan benefits:

• Largest screen on the market with 8 million Oligos on 1 Chip
• CMOS technology ensured Precision and consistency