GenTitan 8 Million Oligo Pool

Pricing for pools 92K and up to 8 million oligos »

Next-Generation MSC DNA Synthesis Technology

Miniature Semiconductor Chip (MSC) enables large-scale de novo synthesis of DNA using proprietary electrochemistry technologies and delivers precision on a microelectrode scale.

ACCURATE SPATIAL CONTROL

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Semiconductor based ensures spatial control over the whole process

ENCLOSED ENVIRONMENT

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Less interference of H2O, O2, O3 and static electricity

CONSISTENCY & UNIFORMITY

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Full chamber reaction with standard wafer and chip production process

Applications

Oligo pools have a wide array of uses in various research applications. Click below to learn more about how GenScript’s oligo pool and related services can meet your application needs.

• Genome Editing ^{Application Note!}

  CRISPR gRNA library

  gRNA libraries are ideal for high-throughput screening of important molecular targets for developing cancer therapeutics and diagnostics as well as microorganism engineering. These libraries leverage the efficiency and specificity of the CRISPR gene editing technology to either knock-out gene expression or transcriptionally activate genes in the genome.

  • GeCKO library for genome-scale knock-out
  • Highly customized gRNA library with oligo pool technology ^New

  shRNA library

  A pooled lentiviral screen can be performed to identify genes that regulate cellular responses and signaling pathways or to discover novel gene functions. Pooled screening libraries can consist of as few as 50 constructs up to many thousands. GenScript’s siRNA Design Center and chip based synthesis platform make the lentivirus-based RNAi libraries available to verify your research hypothesis.

• Protein & Antibody Engineering ^{Application Note!}

  Mutant libraries are used to identify critical residues or regulatory elements and optimize protein structure and function. GenScript offers various mutant libraries customized for your application needs, including industrial & therapeutic enzymes, metabolic & protein engineering and antibody drug development. Our oligo pool synthesis platform allows full control of mutation ratio and creates near 100% coverage of desired variants.

  Library services we offer:

  • Site-directed mutagenesis
  • Scanning point mutation
  • Randomized and degenerated
  • Site saturation and saturation scanning mutagenesis
  • Combinatorial mutagenesis
• NGS Target Enrichment ^{Application Note!}

  Molecular diagnostics based on NGS technology has shown great potential to revolutionize the in vitro diagnostics market. Selectively capturing genomic regions of interest from a DNA sample prior to sequencing reduces the expense of whole genome sequencing and speeds up the discovery process. GenScript’s oligo pool synthesis platform allows high-throughput synthesis of oligos, providing a fast and economic approach to discovery of disease causing mutations or optimization of gene panels in diagnostic kit development.

• Synthetic Biology

  Synthetic biology seeks to make the design, construction, and optimization of biological systems easier, more predictable and reliable. This requires the assembly of DNA circuitry, which can be costly, time-consuming, and complex. GenScript’s oligo pool service allows parallel oligo construction of high sequence fidelity oligos on a large scale, making the creation of synthetic genes and construction of optimized biological systems happen quickly and cost-effectively.