Overview

At GenScript, our GenTitan™ Oligo Pool service offers researchers a comprehensive solution for customized oligonucleotide pools. Using our proprietary high density Complementary Metal Oxide Semiconductor (CMOS) technology, we achieve unmatched precision via microelectrode control, ensuring even distribution and minimal batch differences. Harnessing the industry's largest capacity, with over 8 million oligos on a single chip, our technology empowers breakthroughs in gene editing, protein/antibody engineering, DNA data storage, and more.

Consistency

Consistency

Complete chamber reaction for excellent uniformity

Precision

Precision

Precise control of current and voltage at each electrode

Capacity

Capacity

Up to 8 Million Oligos on a single chip

Technology

Behind the Titans

Discover how our Next-Generation CMOS Technology is pushing the boundaries of DNA Synthesis.

Next-Generation MSC DNA Synthesis Technology

Miniature Semiconductor Chip (MSC) enables large-scale de novo synthesis of DNA using proprietary electrochemistry technologies and delivers precision on a microelectrode scale.

ACCURATE SPATIAL CONTROL

ACCURATE SPATIAL CONTROL


Semiconductor based ensures spatial control over the whole process

ENCLOSED ENVIRONMENT

ENCLOSED ENVIRONMENT


Less interference of H2O, O2, O3 and static electricity

CONSISTENCY & UNIFORMITY

CONSISTENCY & UNIFORMITY


Full chamber reaction with standard wafer and chip production process

Services Specification

We Offer Customized Pricing to Match your Needs (Starting from 1K pool size). Get an Estimated Price with Our Calculator Today!

Oligo Length (10-170nt)

nt
10
30
50
70
90
110
130
150
170nt

Pool Size (0K - 8M)

K pool
0K
1M
2M
3M
4M
5M
6M
7M
8M
Price
From $800

Complete Pricing Table

Applications

Genome Editing 1
NGS Target Enrichment 2
Protein & Antibody Engineering 3
Gene Fragments 4
DNA Data Storage 5

Genome Editing

CRISPR gRNA Library

Oligo pool gRNA libraries, utilizing CRISPR gene editing, enable high-throughput screening for cancer therapy, diagnostics, and microorganism engineering. They facilitate gene knock-out and activation, probing tumorigenesis, biomarkers, and metabolic pathways. This transformative tool leverages CRISPR's precision for versatile biomedical and biotech applications.

shRNA Library

A pooled lentiviral screen can be performed to identify genes regulating cellular responses and signaling pathways, or to uncover novel functions. Libraries can comprise 50 to thousands of constructs. GenScript offers lentivirus-based RNAi libraries through our siRNA Design Center and chip-based synthesis platform, supporting research hypothesis verification.

NGS Target Enrichment

Next-generation sequencing (NGS) target enrichment utilizing oligo pools has emerged as a transformative technique in genomics research. By custom designing pools of oligonucleotide probes complementary to specific genomic regions of interest, researchers can efficiently capture and amplify relevant DNA fragments for sequencing. This approach not only streamlines the sequencing process but also significantly reduces the cost and data burden.

Protein & Antibody Engineering

Mutant libraries are powerful, high-throughput tools for optimizing protein structure and function. However, traditional methods for library construction, including error-prone PCR or degenerate methods, suffer from limited control over codon usage and poor variant representation. Powered by our semiconductor-based oligo synthesis technology, our Precision Mutant Library service offers precise control over each synthesized variant. The result is a more diverse and fully covered mutant library with unbiased distribution.

Library services we offer:

Gene Fragments

Gene Fragments offer a cost-effective, swift, and effective avenue for constructing the requisite genes in your research endeavors. These double-stranded DNA fragments of up to 1,800 base pairs in length, fulfilling the demands of easy gene construction or modification suitable for a variety of applications, including antibody development, CRISPR-mediated genome editing, and NGS controls. The GenTitan™ Gene Fragments Service leverages our exclusive complementary metal oxide semiconductor (CMOS) integrated circuits (IC), ensuring unmatched precision, accelerated delivery schedules, and exceptional cost-effectiveness.

DNA Data Storage

DNA data storage involves encoding digital information as DNA sequences, utilizing the four DNA bases (A, T, C, and G) to represent binary data (0s and 1s). These sequences can be later synthesized into DNA strands for storage. Oligo pools are used to generate these sequences efficiently and in parallel, allowing large amounts of data to be encoded using unique combinations of oligos.

GenTitan benefits:

  • Largest screen on the market with 8 million Oligos on 1 Chip
  • CMOS technology ensured Precision and consistency

Resource

Sgrna Library Application Note

Building a diverse CRISPR gRNA library using arrayed-synthesized oligo pools

Free Download
Oligo Pools Brochure

Cost-effective library construction and efficient high-throughput screening

Free Download
Oligo Pool User Guide

Oligo pools are a collection of thousands of oligonucleotides

Free Download

Get in Touch
with GenScript GenTitan Oligo
Pool Services

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