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Immune-checkpoint Assays

Immune-checkpoint Assays

Immune-checkpoint Assays

Immune checkpoints represent a group of extracellular membrane-bound proteins expressed on immune effector cells (e.g. T/B cells, NK cells), either inhibiting or stimulating effector cell proliferation. They are involved in eliminating foreign pathogens while maintaining self-tolerance, playing a crucial role in immunomodulation. Nowadays, production of therapeutic antibodies designed to block or activate immune checkpoints has become a new powerful approach for the treatment of cancer and other diseases.

To meet the growing demand of drug discovery on immune checkpoint targets, GenScript has developed a suite of cell-based reporter bioassays with high specificity, sensitivity and reproducibility. The bioassays are complied with ICH guidelines with outstanding performance in antibody screening, characterization, potency testing and stability studies.

Key Features:

Immune-checkpoint assay service details

Target Ligand Stimulatory Inhibitory Deliverables Turnaround time
PD1 PDL1   X
  • Final reports including raw data (7 concentrations) and analyzed data;
  • Data include: EC 50, dose-response curves (DRC) for the samples and internal control.
       
5 business days 
PDL1 PD1 X
CTLA-4 CD80/CD86 X
TIGIT CD155 X
LAG3 MHC I/II X
GITR GITRL X  
4-1BB 4-1BBL X
OX40 OX40L X  
CD40 CD40L X

Related services

Co-stimulatory Immune Checkpoint Bioassay

Co-stimulatory Immune Checkpoint Bioassay

Mechanism of action: anti-GITR, anti-4-1BB, anti-OX40 and anti-CD40 antibodies function to mimic the ligand.

Inhibitory Immune Checkpoint Bioassay

Inhibitory Immune Checkpoint Bioassay

Mechanism of action: anti-CTLA-4, anti-TIGIT, anti-PD1, anti-PDL1 and anti-LAG3 antibodies block CTLA-4, TIGIT, PD1, PDL1 and MHC I/II respectively to activate the downstream production of reporter enzyme.

Immune-checkpoint Assays

Quotation and Ordering

Immune-checkpoint Assays Quotations & Ordering

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