HEK293/hERG Stable Cell Line

Inhibition of the cardiac delayed rectifier potassium current (Ikr), which is conducted by hERG (human ether-à-go-go Related Gene), closely predicts the cardiac action potential prolongation by non-cardiac drugs. Such cardiac action potential prolongation may lead to a potentially lethal form of cardiac arrhythmia called torsades-de-pointes (TdP). Therefore, early screening of compounds for hERG channel activity is a vital step in drug discovery processes.