B7-H4 is a transmembrane protein that binds an unknown receptor on activated T cells resulting in inhibition of T-cell effector function via cell cycle arrest, decreased proliferation, and reduced IL-2 production. B7-H4 is up-regulated on the surface of cancer cells and immunosuppressive tumor-associated macrophages (TAMs) in a variety of human cancers.
VTCN1 ; B7H4; B7S1; B7X; B7h.5; PRO1291; VCTN1
|Freeze Medium||95% complete growth medium, 5% DMSO|
|Culture Medium||F12K, 10% FBS, 600 μg/ml G418|
|Storage||Liquid nitrogen immediately upon receiving|
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