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Catalog Products » Other Products » Human Recombinant TIGIT Stable Cell Line

CHO-K1/TIGIT Stable Cell Line


Synonyms WUCAM, Vstm3
Description TIGIT (T cell immunoreceptor with Ig and ITIM domains) was recently characterized as an inhibitory receptor, which is expressed mainly on NK, Treg, CD8+ T, and CD4+ T cells. TIGIT harbors an immunoglobulin tail tyrosine (ITT)-like phosphorylation motif and an ITIM (immunoreceptor tyrosine-based inhibition motif) in its cytoplasmic tail. The poliovirus receptor (PVR or CD155) was identified as the physical ligand of TIGIT with high affinity, and PVRL2 (Nectin2 or CD112) also binds to TIGIT with a weaker binding capacity. TIGIT/PVR engagement suppresses T cell activation through IL-10 secretion mediated by dendritic cells. Furthermore, TIGIT also exerts an intrinsic inhibitory function to T cell activation.
Species human
Culture Medium F12K, 10% FBS, 6 μg/ml Puromycin
Freeze Medium 95% complete growth medium, 5% DMSO

Stability 15 passages
Storage Liquid nitrogen immediately upon receiving

CHO-K1/TIGIT Stable Cell Line
CHO-K1/TIGIT Stable Cell Line

FACS analysis of TIGIT expression in CHO-K1/TIGIT cells.




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Cat. No. M00542
Size
Price
2 vials $8500.00
24 hour
 
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