4-1BB is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), CD137 and induced by lymphocyte activation (ILA). It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule. 4-1BB can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, 4-1BB expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.
ILA; Ly63; 4-1BB; Cd137; CDw137; TNFRSF9
|Freeze Medium||95% complete growth medium, 5% DMSO|
|Culture Medium||F12K, 10% FBS, 8 μg/ml Puromycin|
|Storage||Liquid nitrogen immediately upon delivery|
|Binding assay or use as immunogen|
For more documents, please visit "Technical Support".