BDCA-2 is a novel type II C-type lectin, which shows 50.7% sequence identity at the amino acid level to its putative murine ortholog, the murine dendritic cell–associated C-type lectin 2. In addition to its antigen capturing function, BDCA-2 can mediate potent inhibition of induction of IFN-α/β expression in PDCs. Production of IFN-α/β in response to several different types of viruses, bacteria, CpG-DNA, dsRNA, and SLE serum is by far the most prominent feature of PDCs.
|Freeze Medium||95% complete growth medium, 5% DMSO|
|Culture Medium||F12K, 10% FBS, 8 μg/ml Puromycin|
|Storage||Liquid nitrogen immediately upon receiving|
|Binding assay or use as immunogen|
For more documents, please visit "Technical Support".