|Synonyms||Btdc; B7-DC ; PDCD1LG2|
|Description||Programmed cell death 1 ligand 2 (PD-L2) is a protein that is encoded by the PDCD1LG2 gene in humans. PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273). Inhibitory molecules of the B7/CD28 family play a key role in the induction of immune tolerance in the tumor microenvironment. The programmed death-1 receptor (PD-1), with its ligands PD-L1 and PD-L2, constitutes an important member of these inhibitory pathways. PD-L2 expression was initially thought to be restricted to antigen-presenting cells such as macrophages and dendritic cells (DCs). However, PD-L2 expression can be induced on a wide variety of other immune cells and nonimmune cells depending on micro environmental stimuli.|
|Culture Medium||F12K, 10% FBS, 8 μg/ml Puromycin|
|Freeze Medium||95% complete growth medium, 5% DMSO|
|Storage||Liquid nitrogen immediately upon receiving|
|Binding assay or use as immunogen
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