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CHO-K1/KIR Stable Cell Line

FACS analysis of KIR expression in CHO-K1 cells.

CHO-K1/KIR Stable Cell Line

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and are subsets of T cells. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
M00650
$8,500.00

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Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and are subsets of T cells. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Synonyms

NKAT; NKAT1; p58.1; CD158A; KIR221; NKAT-1; KIR-K64

Overview
Applications Binding assay or use as immunogen

Product Introduction
Storage Liquid nitrogen immediately upon receiving
Species Human
Stability 15 passages

Culture Conditions
Freeze Medium 95% complete growth medium, 5% DMSO
Culture Medium F12K, 10% FBS, 8 μg/ml Puromycin

Examples
  • CHO-K1/KIR Stable Cell Line
  • CHO-K1/KIR Stable Cell Line

    FACS analysis of KIR expression in CHO-K1 cells.


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