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CREBtide

*This product has been discontinued!*
CREBtide is a synthetic substrate for PKA (Km=3.9 µM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein). The rate of CREBtide phosphorylation was at least as great as that of delta-CREB, indicating that CREBtide retained the determinants of delta-CREB which were responsible for substrate efficacy.
RP10142
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Overview
Description CREBtide is a synthetic substrate for PKA (Km=3.9 µM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein). The rate of CREBtide phosphorylation was at least as great as that of delta-CREB, indicating that CREBtide retained the determinants of delta-CREB which were responsible for substrate efficacy.
Sequence
{LYS}{ARG}{ARG}{GLU}{ILE}{LEU}{SER}{ARG}{ARG}{PRO}{SER}{TYR}
{ARG}
Sequence Shortening KRREILSRRPSYR
Molecular Formula C73H129N29O19
Molecular Weight 1717.0
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Properties
Purity > 95%
Solubility Soluble in water
Form Lyophilized
Storage Store at -20°C.
Note Peptide corresponding to the consensus phosphorylation site at Ser133 of the cyclic AMP response element binding protein (CREB).
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