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Substance P

Substance P is found in the gut and in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons. Substance P contracts smooth muscle, constricts bronchioles, and increases capillary permeability. When released from afferent nerves, Substance P causes a neurogenic inflammatory response, including mast cell degranulation. It's an NK-1 agonist; a potent vasodilator and hypotensive agent; it induces salivation; it's a putative neurotransmitter in sensory (pain) afferents.
RP10178
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Overview
Description Substance P is found in the gut and in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons. Substance P contracts smooth muscle, constricts bronchioles, and increases capillary permeability. When released from afferent nerves, Substance P causes a neurogenic inflammatory response, including mast cell degranulation. It's an NK-1 agonist; a potent vasodilator and hypotensive agent; it induces salivation; it's a putative neurotransmitter in sensory (pain) afferents.
Cas No 33507-63-0
Sequence
{ARG}{PRO}{LYS}{PRO}{GLN}{GLN}{PHE}{PHE}{GLY}{LEU}{MET}-NH2
Sequence Shortening RPKPQQFFGLM-NH2
Molecular Formula C63H98N18O13S1
C Terminal NH2
Molecular Weight 1347.63

Properties
Purity > 95%
Solubility Soluble in water (1 mg/ml)
Form Lyophilized
Storage Store the peptide at -20°C. Keep container tightly closed.


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