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Catalog Products » Other Products » Catalog Peptides » All Catalog Peptides » Substance P

Substance P

Description Substance P is found in the gut and in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons. Substance P contracts smooth muscle, constricts bronchioles, and increases capillary permeability. When released from afferent nerves, Substance P causes a neurogenic inflammatory response, including mast cell degranulation. It's an NK-1 agonist; a potent vasodilator and hypotensive agent; it induces salivation; it's a putative neurotransmitter in sensory (pain) afferents.
Cas No 33507-63-0
Sequence
{ARG}{PRO}{LYS}{PRO}{GLN}{GLN}{PHE}{PHE}{GLY}{LEU}{MET}-NH2
Sequence Shortening RPKPQQFFGLM-NH2
Molecular Formula C63H98N18O13S1
C Terminal NH2
Molecular Weight 1347.63

Purity > 95%
Solubility Soluble in water (1 mg/ml)
Gmp Flag 0
Anaspec Cat No Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Storage Store the peptide at -20°C. Keep container tightly closed.
Note

  • Substance P
  • Substance P


Cat. No.
Product Name
Price
RP10210
[Sar9]-Substance P - 1 mg
$33.00
RP10207
[Nle11]-Substance P - 1 mg
$24.00
RP10185
Substance P, Free Acid - 5 mg
$43.00
RP10182
Substance P (7-11) - 1 mg
$24.00
RP10181
Substance P (1-9) - 1 mg
$24.00
RP10180
Substance P (1-7) - 1 mg
$24.00
 
Wick EC, et al. Transient receptor potential vanilloid 1, et al. calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. May 2006;290(5):G959-969.

Allen JW, et al. Safety Evaluation of Intrathecal Substance P-Saporin, a Targeted Neurotoxin, in Dogs. Toxicol Sci. May 2006;91(1):286-298.

Lindenburg PW., et al. On-line large-volume electroextraction coupled to liquid chromatography–mass spectrometry to improve detection of peptides. J Chromatogr A. 2012 Aug;124917-24.

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Cat. No. RP10178
Size
Price
5 mg $43.00