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Catalog Products » Other Products » Catalog Peptides » All Catalog Peptides » [Nle11]-Substance P

[Nle11]-Substance P

Description Substance P was found in the gut as well as in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons. Substance P contracts smooth muscle, constricts bronchioles and increases capillary permeability. When released from afferent nerves, Substance P causes a neurogenic inflammatory response, including mast cell degranulation. NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; putative neurotransmitter in sensory (pain) afferents. [Nle11]-Substance P is a Substance P analog that avoids methionine oxidation problems.
Cas No 57462-42-7
Sequence
{ARG}{PRO}{LYS}{PRO}{GLN}{GLN}{PHE}{PHE}{GLY}{LEU}{NLE}-NH2
Sequence Shortening RPKPQQFFGL-Nle-NH2
Molecular Formula C64H100N18O13
C Terminal NH2
Molecular Weight 1329.59

Purity > 95%
Gmp Flag 0
Storage Store at -20°C. Keep tightly closed. Store in a cool dry place.
Note

  • [Nle<sup>11</sup>]-Substance P
  • [Nle<sup>11</sup>]-Substance P


Cat. No.
Product Name
Price
RP10210
[Sar9]-Substance P - 1 mg
$33.00
RP10185
Substance P, Free Acid - 5 mg
$43.00
RP10182
Substance P (7-11) - 1 mg
$24.00
RP10181
Substance P (1-9) - 1 mg
$24.00
RP10180
Substance P (1-7) - 1 mg
$24.00
RP10178
Substance P - 5 mg
$43.00
 
Wick EC, et al. Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis. Am. J. Physiol. Gastrointest Liver Physiol. May 2006; 290(5): G959-969.

Rohleder N, et al. No response of plasma substance P, but delayed increase of interleukin-1 receptor antagonist to acute psychosocial stress. Life Sci. May 2006; 78(26): 3082-3089.

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Cat. No. RP10207
Size
Price
1 mg $24.00