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Catalog Products » Other Products » Catalog Peptides » All Catalog Peptides » Melittin

Melittin

Description This 26-residue polypeptide isolated from bee venom binds calmodulin in a Ca2+-dependent manner, activates phospholipase A2, and inhibits protein kinase C (IC50=5-7 mM) by binding to the catalytic domain in a Mg-ATP-sensitive manner.
Cas No 20449-79-0
Sequence
{GLY}{ILE}{GLY}{ALA}{VAL}{LEU}{LYS}{VAL}{LEU}{THR}{THR}{GLY}{LEU}{PRO}{ALA}{LEU}{ILE}{SER}{TRP}{ILE}{LYS}{ARG}{LYS}{ARG}{GLN}{GLN}-NH2
Sequence Shortening GIGAVLKVLTTGLPALISWIKRKRQQ-NH2
Molecular Formula C131H229N39O31
C Terminal NH2
Molecular Weight 2846.46

Purity > 95%
Gmp Flag 0
Storage Store at -20°C
Note Polypeptide from honey bee venom

  • Melittin
  • Melittin


Saugar JM, et al. Activity of cecropin A-melittin hybrid peptides against colistin-resistant clinical strains of Acinetobacter baumannii: molecular basis for the differential mechanisms of action. Antimicrob Agents Chemother. Apr 2006;50(4):1251-1256.

Loutet SA, et al. A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo. J Bacteriol. Mar 2006;188(6):2073-2080.

Shank LP, et al. Redesigning channel-forming peptides: amino acid substitutions that enhance rates of supramolecular self-assembly and raise ion transport activity. Biophys J. Mar 15 2006;90(6):2138-2150.

NW Palm., etc. Role of the inflammasome in defense against venoms. Proc Natl Acad Sci U S A. 2013 Jan;110(5):1809-14.

Hood JL., etc. Cytolytic nanoparticles attenuate HIV-1 infectivity. Antivir Ther. 2012 Sep;18(1):95-103.

Tina Y. Liu., etc. Pnas Plus: Lipid Interaction Of The C Terminus And Association Of The Transmembrane Segments Facilitate Atlastin-Mediated Homotypic Endoplasmic Reticulum Fusion. Proc Natl Acad Sci U S A. 20

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Cat. No. RP10290
Size
Price
0.5 mg $90.00
1 mg $157.00