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Home » Gene Synthesis & Molecular Biology Services » PACAP (6-38), human, ovine, rat

PACAP (6-38), human, ovine, rat

Description PACAP (6-38) is a potent antagonist of PACAP 38. PACAP (6-38) is much more potent and selective than PACAP (6-27) in the inhibition of PACAP-27-stimulated pituitary adenylate cyclase. Ki values for the inhibition of the enzyme were 7nM and 150 nM, respectively. PACAP (6-38) caused a small but significant (approximately 20%) inhibition of the NANC relaxation due to electrical field stimulation (1 Hz or 10 Hz for 20 s). At these frequencies PACAP (6-38) caused no inhibition of the NANC relaxation in the presence of the P2 purinoceptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (or PPADS) plus the NO-synthase blocker NG-nitro-L-arginine; in preparations pretreated with L-NOARG alone, PACAP (6-38) retained its inhibitory effect.
Sequence
{PHE}{THR}{ASP}{SER}{TYR}{SER}{ARG}{TYR}{ARG}{LYS}{GLN}{MET}{ALA}{VAL}{LYS}{LYS}{TYR}{LEU}{ALA}{ALA}{VAL}{LEU}{GLY}{LYS}{ARG}{TYR}{LYS}{GLN}{ARG}{VAL}{LYS}{ASN}{LYS}-NH2
Sequence Shortening FTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH2
Molecular Formula C182H300N56O45S1
C Terminal NH2
Molecular Weight 4024.76

Purity > 95%
Solubility Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents.
Gmp Flag 0
Anaspec Cat No Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
Storage Store the peptide at -20°C.
Note This peptide is a potent agonist.


Cat. No.
Product Name
Price
RP10341-0.5
PACAP-Related Peptide (PRP), human - 0.5 mg
$138.00
RP10335-0.5
PACAP (1-38), human, ovine, rat - 0.5 mg
$142.00
RP10334-0.5
PACAP (1-27), human, ovine, rat - 0.5 mg
$104.00
 


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Cat. No. RP10338
Size
Price
0.5 mg $133.00