[Gln^{8, 9}]-Helodermin

[Gln8, Gln9] Helodermin is a peptide that [Glu8, Glu9] of Helodermin are replaced by [Gln8, Gln9]. Some studies show that helodermin on vascular physiology has effect on anesthetized dogs using a synthetic replicate of helodermin and helodermin related peptides. Intraarterial infusion of helodermin caused a dose-dependent increase in femoral blood flow. Helodermin was 16 times less potent than VIP and 5 times more potent than PHM (human PHI). The results demonstrate the VIP-like vasodilating activity and cardiovascular effects of helodermin in anesthetized dogs.