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Home » Gene Synthesis & Molecular Biology Services » Leptin (22-56), human

Leptin (22-56), human

Description Leptin (22-56), a biological active fragment of Leptin, may have important physiological significance for the anorexia, hypogonadism, and anaemia commonly seen in HD patients. Leptin (22-56), at concentrations of 10(-7) and 10(-6) M, enhance the proliferative activity of both the normal myometrium and myoma cells in primary culture.
Sequence
{VAL}{PRO}{ILE}{GLN}{LYS}{VAL}{GLN}{ASP}{ASP}{THR}{LYS}{THR}
{LEU}{ILE}{LYS}{THR}{ILE}{VAL}{THR}{ARG}{ILE}{ASN}{ASP}{ILE}
{SER}{HIS}{THR}{GLN}{SER}{VAL}{SER}{SER}{LYS}{GLN}{LYS}
Sequence Shortening VPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQK
Molecular Formula C171H298N50O56
Molecular Weight 3950.52

Purity > 95%
Solubility Insoluble in water. Dissolve peptide with small amount of 60% Acetonitrile with 0.1% TFA solution - followed with water or desired buffer.
Gmp Flag 0
Storage Store at -20°C
Note ICV injection (500 ng) reduces food intake in rats.


Markowska A, et al. Leptin and leptin receptor expression in the myometrium and uterine myomas: Is leptin involved in tumor development? Int. J. Oncol. Dec 2005; 27(6): 1505-1509.

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Cat. No. RP10702
Size
Price
0.5 mg $142.00