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Catalog Products » Other Products » Catalog Peptides » All Catalog Peptides » Galanin Receptor Ligand M35

Galanin Receptor Ligand M35

Description The chimeric peptide M35 [galanin (1-13)-bradykinin(2-9) amide] is a high-affinity galanin receptor ligand acting as a galanin receptor antagonist in the rat spinal cord, rat hippocampus and isolated mouse pancreatic islets. The radiolabelled M35 and performed equilibrium binding studies with [125I] M35 on the rat pancreatic beta-cell line Rin m 5F. Galanin displaces [125I] M35 with the same affinity (KD = 1 nM) as it displaces [125I] galanin. Displacement of [125I] galanin by M35 from Rin m 5F cell membranes shows the presence of two binding sites for M35 with KD-values of 0.3 +/- 0.1 nM and 0.52 +/- 0.03 µM, respectively.
Sequence
{GLY}{TRP}{THR}{LEU}{ASN}{SER}{ALA}{GLY}{TYR}{LEU}{LEU}{GLY}{PRO}{PRO}{PRO}{GLY}{PHE}{SER}{PRO}{PHE}{ARG}-NH2
Sequence Shortening GWTLNSAGYLLGPPPGFSPFR-NH2
Molecular Formula C107H153N27O26
C Terminal NH2
Molecular Weight 2233.6

Purity > 95%
Solubility Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
Gmp Flag 0
Anaspec Cat No Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-NH2
Storage Store at -20°C
Note


Kwong SM, et al. Replication Control of Staphylococcal Multiresistance Plasmid pSK41: an Antisense RNA Mediates Dual-Level Regulation of Rep Expression. J.Bacteriol. Jun 2006; 188(12): 4404-4412.

Tomas A, et al. Regulation of pancreatic {beta}-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway. J.Cell.Sci. May 2006; 119(10): 2156-2167.

Kwong SM, et al. Polymorphic Fibril Formation by Residues 10-40 of the Alzheimer's {beta}-Amyloid Peptide. Biophys.J. Jun 2006; 90(12): 4618-4629.

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Cat. No. RP10808
Size
Price
0.5 mg $71.00