|Synonyms||Fibrinogen Binding Inhibitor|
|Description||Fibrinogen Binding Inhibitor Peptide, a synthetic dodecapeptide, represents the specific platelet receptor recognition site of the human fibrinogen g-chain (residues 400-411). It is also a potent inhibitor of the binding of fibrinogen, fibronectin, and von Willebrand factor to thrombin- or ADP-stimulated platelets. Fibrinogen Binding Inhibitor Peptide has been used in studying phosphorylation processes associated with platelet activation.|
|Solubility||Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.|
|Storage||Before using, store the peptide in the DRY form at 0-5°C. For best and repeatable results, rehydrate the peptide immediately before using. Do not re-freeze any unused portions.|
|Note||In activated platelets, single γ 400-411 sequence is no longer required for initiation of adhesion but becomes sufficient for firm adhesion. In contrast to the binding of whole fibrinogen, binding of fragment 400-411 does not lead to tyrosine phosphorylation for platelet proteins.|
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