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Catalog Products » Other Products » Catalog Peptides » All Catalog Peptides » Gly-Arg-Gly-Asp-Asn-Pro

Gly-Arg-Gly-Asp-Asn-Pro

Synonyms GRGDNP; GLY-ARG-GLY-ASP-ASN-PRO
Description G-R-G-D-N-P is a superior inhibitor of cell attachment to fibronectin and a weak inhibitor of cell attacment to vitronectin. It also inhibits binding of fibrinogen, fibronectin, vitronectin and von Willebrand factor to platelets and resists to carboxypeptidases. G-R-G-D-N-P induces apoptosis in various cell types and cell lines at 1mM by a mechanism involving cellular uptake and possible direct stimulation of procaspase-3 autoprocessing. It contains the motif RGD (Arg-Gly-Asp) which is found in many integrin ligands. G-R-G-D-N-P inhibits cell adhesion to fibronectin 80-90% at 1 mM.
Cas No 114681-65-1
Sequence
{GLY}{ARG}{GLY}{ASP}{ASN}{PRO}
Sequence Shortening GRGDNP
Molecular Formula C23H38N10O10
Molecular Weight 614.6

Purity > 95%
Gmp Flag 0
Storage Store at -20°C. Keep tightly closed. Store in a cool dry place.
Note


Sarin V, et al. Arginine-glycine-aspartic acid (RGD)-containing peptides inhibit the force production of mouse papillary muscle bundles via alpha 5 beta 1 integrin. J. Physiol. Apr 2005; 564(Pt 2): 603-617.

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Cat. No. RP10847
Size
Price
1 mg $24.00