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Catalog Products » Other Products » Catalog Peptides » All Catalog Peptides » Endomorphin-1

Endomorphin-1

Synonyms Endomorphin1; EM-1; EM1
Description Endomorphin-1 (EM-1) is a recently isolated endogenous peptide having potent analgesic activity and high affinity and selectivity for the mu-opioid receptor. Endomorphin-1 activates G proteins and inhibits adenylyl cyclase activity in membrane preparations from cells stably expressing the mu opioid receptor, an effect reversed by the mu receptor antagonist CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2). However, endomorphin-1 appears to have no influence on cells stably expressing the delta opioid receptor.
Cas No 189388-22-5
Sequence
{TYR}{PRO}{TRP}{PHE}-NH2
Sequence Shortening YPWF-NH2
Molecular Formula C34H38N6O5
C Terminal NH2
Molecular Weight 610.7

Purity > 95%
Solubility The peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents.
Gmp Flag 0
Anaspec Cat No Tyr-Pro-Trp-Phe-NH2
Storage Store the peptide at -20°C. Keep container tightly closed.
Note Endomorphin-1 is a potent, selective endogenous μ opioid receptor agonist.

  • Endomorphin-1
  • Endomorphin-1


Cat. No.
Product Name
Price
RP10926
Endomorphin-2 - 5 mg
$43.00
 
Botros M, et al. Endomorphin-1 and endomorphin-2 differentially interact with specific binding sites for substance P (SP) aminoterminal SP(1-7) in the rat spinal cord.. Peptides. Apr 2006; 27(4): 753-739.

Okutsu H, et al. Endomorphin-2 and Endomorphin-1 Promote the Extracellular Amount of Accumbal Dopamine via Nonopioid and Mu-Opioid Receptors, Respectively. Neuropsychopharmacology. Feb 2006; 31(2): 375-383.

Leng DN, et al. Endomorphin-1 is more potent than endomorphin-2 in inhibition of synaptic transmission in substantia gelatinosa of adult rat spinal cord. Int. J. Neurosci. Nov 2005; 115(11): 1515-1526.

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Cat. No. RP10925
Size
Price
5 mg $43.00