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Endomorphin-1

*This product has been discontinued!*
Endomorphin-1 (EM-1) is a recently isolated endogenous peptide having potent analgesic activity and high affinity and selectivity for the mu-opioid receptor. Endomorphin-1 activates G proteins and inhibits adenylyl cyclase activity in membrane preparations from cells stably expressing the mu opioid receptor, an effect reversed by the mu receptor antagonist CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2). However, endomorphin-1 appears to have no influence on cells stably expressing the delta opioid receptor.
RP10925
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Description

Endomorphin-1 (EM-1) is a recently isolated endogenous peptide having potent analgesic activity and high affinity and selectivity for the mu-opioid receptor. Endomorphin-1 activates G proteins and inhibits adenylyl cyclase activity in membrane preparations from cells stably expressing the mu opioid receptor, an effect reversed by the mu receptor antagonist CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2). However, endomorphin-1 appears to have no influence on cells stably expressing the delta opioid receptor.

Synonyms

Endomorphin1; EM-1; EM1

Note

Endomorphin-1 is a potent, selective endogenous μ opioid receptor agonist.

Overview
Cas No 189388-22-5
Sequence
{TYR}{PRO}{TRP}{PHE}-NH2
Sequence Shortening YPWF-NH2
Molecular Formula C34H38N6O5
C Terminal NH2
Molecular Weight 610.7
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Properties
Purity > 95%
Solubility The peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents.
Storage Store the peptide at -20°C. Keep container tightly closed.
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