|Description||Apamin, a bee venom polypeptide, blocks specifically the Ca2+-dependent K+ channels that are not blocked by tetraethylammonium chloride in muscle cells. Apamin is a highly specific compound that tightly binds to the Ca2+ slow channels, thus blocking the slow APs in heart muscle. In addition, quinidine antagonizes the apamin binding on the slow APs.|
|Disulfide Bridge||Disulfide Bridge Cys1-Cys11 and Cys3-Cys15|
|Storage||Store at -20°C. Keep tightly closed. Store in a cool dry place.|
|Note||Originally isolated from Apis mellifera. A small conductance Ca2+-activated K+ channel blocker.|
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