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Home » Gene Synthesis & Molecular Biology Services » Apamin

Apamin

Description Apamin, a bee venom polypeptide, blocks specifically the Ca2+-dependent K+ channels that are not blocked by tetraethylammonium chloride in muscle cells. Apamin is a highly specific compound that tightly binds to the Ca2+ slow channels, thus blocking the slow APs in heart muscle. In addition, quinidine antagonizes the apamin binding on the slow APs.
Cas No 24345-16-2
Sequence
{CYS}{ASN}{CYS}{LYS}{ALA}{PRO}{GLU}{THR}{ALA}{LEU}{CYS}{ALA}{ARG}{ARG}{CYS}{GLN}{GLN}{HIS}-NH2
Sequence Shortening CNCKAPETALCARRCQQH-NH2
Molecular Formula C79H131N31O24S4
C Terminal NH2
Disulfide Bridge Disulfide Bridge Cys1-Cys11 and Cys3-Cys15
Molecular Weight 2027.3

Purity > 95%
Format Bridge 1-11,3-15
Gmp Flag 0
Storage Store at -20°C. Keep tightly closed. Store in a cool dry place.
Note Originally isolated from Apis mellifera. A small conductance Ca2+-activated K+ channel blocker.

  • Apamin
  • Apamin


Kato M, et al. SK Channel Blocker Apamin Inhibits Slow Afterhyperpolarization Currents in Rat Gonadotropin-Releasing Hormone Neurones. J. Physiol. 2006 Apr.

Deschaux O, Bizot JC. Apamin produces selective improvements of learning in rats. Neurosci. Lett. Sep 2005; 386(1): 5-8.

Mpari B, et al. Differential effects of two blockers of small conductance Ca2+-activated K+ channels, apamin and lei-Dab7, on learning and memory in rats. J. Integr. Neurosci. Sep 2005; 4(3): 381-396.

Dana V. Skarra., etc. CyPPA, a positive modulator of small-conductance Ca2+-activated K+ channels, inhibits phasic uterine contractions and delays preterm birth in mice. Am J Physiol Cell Physio

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Cat. No. RP11002
Size
Price
0.5 mg $62.00