Myelin Basic Protein (MBP) (1-11), human

MBP (1-11) is the major encephalitogenic epitope of the myelin basic protein molecule. The synthetic myelin basic protein MBP (1-11) peptide has been tested in vivo for induction of experimental autoimmune encephalomyelitis (EAE). Myelin basic protein (MBP) is a hydrophilic protein that may help myelin maintain its structure, interacting with the lipids in the myelin membrane by electrostatic and hydrophobic interactions. Myelin basic protein (MBP) is the target of many post-translational modifications: it is N-terminally acetylated, methylated on an arginine residue, phosphorylated by various serine/threonine protein-kinases, and deamidated on some glutamine residues.