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Home » Gene Synthesis & Molecular Biology Services » TAT

TAT

Description TaT is a transcriptional transactivator protein that binds to a regulatory element in the HIV-1 long terminal repeat. By recruiting P-TEFb to TAR, TaT promotes transcription of viral mRNA. This arginine-rich TAT peptide penetrates plasma membrane directly, but not through endocytosis. TaT has similar immunosuppressive effects as transforming growth factor-beta (TGF beta) and both inhibit lymphocyte proliferation.
Sequence
{TYR}{GLY}{ARG}{LYS}{LYS}{ARG}{ARG}{GLN}{ARG}{ARG}{ARG}-NH2
Sequence Shortening YGRKKRRQRRR-NH2
Molecular Formula C64H119N33O13
C Terminal NH2
Molecular Weight 1558.85

Purity > 95%
Gmp Flag 0
Anaspec Cat No Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2
Storage Store at -20°C. Keep tightly closed. Store in a cool dry place.
Note

  • TAT
  • TAT


Cat. No.
Product Name
Price
RP10131-0.5
TAT 2-4 - 0.5 mg
$81.00
 
Kittiworakarn J, et al. HIV-1 Tat raises an adjuvant-free humoral immune response controlled by its core region and its ability to form cysteine-mediated oligomers. J. Biol. Chem. Feb 2006; 281(6): 3105-3115.

Mondal D, et al. The HIV-1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells. Exp. Biol. Med.(Maywood). Oct 2005; 230(9): 631-644.

Hoque M, et al. Granulin and granulin repeats interact with the Tat.P-TEFb complex and inhibit Tat transactivation. J. Biol. Chem. Apr 2005; 280(14): 13648-13657.

Sarah M. Wilson., etc. Inhibition Of Transmitter Release And Attenuation Of Anti-Retroviral-Associated And Tibial Nerve Injury-Related Painful Peripheral Neuropathy By Novel Synthetic Ca2+ Channel Peptides. J Biol Ch

Sunavala-Dossabhoy G., etc. TAT-mediated delivery of tousled protein to salivary glands protects against radiation-induced hypofunction. Int J Radiat Oncol Biol Phys. 2012 Sep;84(1):257-65.

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Cat. No. RP12784
Size
Price
0.5 mg $43.00