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Catalog Products » Other Products » Catalog Peptides » All Catalog Peptides » IRL-1620

IRL-1620

Synonyms IRL-1620; IRL1620
Description IRL-1620 significantly enhanced delivery and effectiveness of paclitaxel in an animal model of breast cancer. IRL-1620 together with IRL-1038 (Prod. No. ALX-155-007) is an indispensable pharmacological tool to assess the participation of the ETB receptor in some pathophysiological phenomena, by selectively stimulating ETB receptor-mediated responses in various pathophysiological models established in vitro and in vivo.
Cas No 142569-99-1
Sequence
Suc-[Glu9Ala11,15]-Endothelin-1(8-21)Suc-Asp-Glu-Glu-Ala-Val
-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp
Sequence Shortening Suc-[Glu9Ala11,15]-Endothelin-1(8-21)Suc-DEEAVYFAHLDIIW
Molecular Formula C86H117N17O27
Molecular Weight 1820.95

Purity > 95%
Solubility Insoluble in water. Dissolve the content with > pH 8.5 buffer.
Gmp Flag 0
Storage Store at -20°C.
Note This peptide is most potent and specific ligand for the ETB receptor (KiETA/KiETB=120 000) as judged by the Ki values for ETA (1.9 µM) and ETB (16 pM) receptors. IRL1620 (10-9-10-7 µM) induced contraction of the guinea pig tracheal with a comparable potency to those of ET-1 or ET-3.


Wang X, et al. Hypoxia-induced reactive oxygen species downregulate ETB receptor-mediated contraction of rat pulmonary arteries. Am. J. Physiol. Lung Cell Mol. Physiol. Mar 2006; 290(3): L570-578.

Rossi NF, et al. Nitric oxide modulation of ET(B) receptor-induced vasopressin release by rat and mouse hypothalamo-neurohypophyseal explants. Am. J. Physiol. Regul. Integr. Comp. Physiol. May 2006; 290(5): R1208-1215.

Rai A, et al. Effect of the ET(B) receptor agonist, IRL-1620, on paclitaxel plasma pharmacokinetics of breast tumor rats. Exp. Biol. Med. (Maywood). Jun 2006; 231(6): 1120-1122.

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Cat. No. RP13497
Size
Price
0.2 mg $33.00