Catalog Products » Catalog Peptide » IRL-1620
Manual
COAs
HPLC
MS

IRL-1620

*This product has been discontinued!*
IRL-1620 significantly enhanced delivery and effectiveness of paclitaxel in an animal model of breast cancer. IRL-1620 together with IRL-1038 (Prod. No. ALX-155-007) is an indispensable pharmacological tool to assess the participation of the ETB receptor in some pathophysiological phenomena, by selectively stimulating ETB receptor-mediated responses in various pathophysiological models established in vitro and in vivo.
RP13497
Ask us a question
Description

IRL-1620 significantly enhanced delivery and effectiveness of paclitaxel in an animal model of breast cancer. IRL-1620 together with IRL-1038 (Prod. No. ALX-155-007) is an indispensable pharmacological tool to assess the participation of the ETB receptor in some pathophysiological phenomena, by selectively stimulating ETB receptor-mediated responses in various pathophysiological models established in vitro and in vivo.
Synonyms

IRL-1620; IRL1620

Note

This peptide is most potent and specific ligand for the ETB receptor (KiETA/KiETB=120 000) as judged by the Ki values for ETA (1.9 µM) and ETB (16 pM) receptors. IRL1620 (10-9-10-7 µM) induced contraction of the guinea pig tracheal with a comparable potency to those of ET-1 or ET-3.

Overview
Cas No 142569-99-1
Sequence
Suc-[Glu9Ala11,15]-Endothelin-1(8-21)Suc-Asp-Glu-Glu-Ala-Val
-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp
Sequence Shortening Suc-[Glu9Ala11,15]-Endothelin-1(8-21)Suc-DEEAVYFAHLDIIW
Molecular Formula C86H117N17O27
Molecular Weight 1820.95
Back

Properties
Purity > 95%
Solubility Insoluble in water. Dissolve the content with > pH 8.5 buffer.
Storage Store at -20°C.
Back