Catalog Products » Catalog Peptide » PAR-1 agonist peptide
Manual
COAs
HPLC
MS

PAR-1 agonist peptide

*This product has been discontinued!*
This hexapeptide corresponding to residues 42-47 of the thrombin receptor has been shown to be a thrombin receptor activator. It caused half-maximal platelet aggregation at approx. 0.8 uM and was 5 times more potent than the parent peptide H-8105. In addition, SFLLRN is effective in causing tyrosine phosphorylation, inhibition of cAMP formation, and an increase in cytosolic Ca2+.
RP19979
Ask us a question
Description

This hexapeptide corresponding to residues 42-47 of the thrombin receptor has been shown to be a thrombin receptor activator. It caused half-maximal platelet aggregation at approx. 0.8 uM and was 5 times more potent than the parent peptide H-8105. In addition, SFLLRN is effective in causing tyrosine phosphorylation, inhibition of cAMP formation, and an increase in cytosolic Ca2+.
Overview
Sequence
{Ser}{Phe}{Leu}{Leu}{Arg}{Asn}
Sequence Shortening SFLLRN
Molecular Formula C34H56N10O9
Molecular Weight 748.87
Back

Properties
Purity 95%
Storage Store at -20°C.
Back

Citations
Carmo AA, et al. Plasmin induces in vivo monocyte recruitment through protease-activated receptor-1-, MEK/ERK-, and CCR2-mediated signaling. J Immunol. (2014)