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Catalog Products » Other Products » Catalog Peptides » Beta Amyloid Peptides » β-Amyloid (22-35)

β-Amyloid (22-35)

Synonyms Beta-Amyloid (22-35)
Description Beta amyloid (22-35) is a synthetic truncated fragment of beta-amyloid peptide. It has been demonstrated that beta amyloid (22-35) possesses a cytotoxic effect on cultured rat hippocampus neurons in serum-free medium. Aggregates and typical amyloid fibrils resembling those of the beta amyloid protein (AP) are formed in neutral buffer solution from beta amyloid (22-35). These fibrils show characteristic staining with Congo red and thioflavin-S. The neurotoxicity of beta amyloid (22-35) can be suppressed by addition of calf serum, dibutyryl cAMP, or insulin to the culture medium. However, the addition of NGF or substance P will not suppress the neurotoxicity. Beta amyloid (22-35) does not act on glial cells. These results suggest that AP can induce neurotoxicity in hippocampal cells in vitro and may result in a disorder involving intracellular signal transduction.
Cas No 144189-71-9
Sequence
{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}
{Leu}{Met}
Sequence Shortening EDVGSNKGAIIGLM
Molecular Formula C59H102N16O21S
Molecular Weight 1403.61

Purity > 95%
Solubility Soluble in water.
Gmp Flag 0
Storage Store at -20°C. Keep tightly closed. Store in a cool dry place.
Note




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Cat. No. RP20130
Size
Price
1 mg $86.00
5 mg $380.00