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Catalog Products » Other Products » Catalog Peptides » All Catalog Peptides » G3-C12

G3-C12

Description Galectin-3 is a member of the galectin family of beta-galactoside-binding animal lectins. Galectin-3 is overexpressed in a wide range of neoplasms and is associated with tumor growth and metastases. Given this fact, radiolabeled galectin-3-targeting molecules may be useful for the noninvasive imaging of tumors expressing galectin-3, as well as for targeted radionuclide therapy. In this study, the tumor cell-targeting and SPECT properties of a galectin-3-avid peptide identified from bacteriophage display were evaluated in human breast carcinoma cells and in human breast tumor-bearing mice. The galectin-3-avid peptide G3-C12 (ANTPCGPYTHDCPVKR) was synthesized with a Gly-Ser-Gly (GSG) linker at the amino terminus.
Sequence
{Ala}{Asn}{Thr}{Pro}{Cys}{Gly}{Pro}{Tyr}{Thr}{His}{Asp}{Cys}
{Pro}{Val}{Lys}{Arg}
Sequence Shortening ANTPCGPYTHDCPVKR
Molecular Formula C74H115N23O23S2
Molecular Weight 1758.98

Purity >95%
Storage Store at -20°C.
Note


Kumar SR,J Nucl Med. 2008 May;49(5):796-803. Epub 2008 Apr 15.

Newton-Northup JR., et al. Inhibition of metastatic tumor formation in vivo by a bacteriophage display-derived galectin-3 targeting peptide. Clin Exp Metastasis. 2013 Apr;30(2):119-132.

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Cat. No. RP20329
Size
Price
1 mg $50.00