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Catalog Products » Other Products » Catalog Peptides » All Catalog Peptides » InsB 9-23

InsB 9-23

Description This insulin B-chain peptide binds to a class II histocompatibility complex (MHC) allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic ß cells leading to hyperglycemia. This insulin B peptide may be a self-antigen candidate that could initiate the disease. Immunization with this peptide in mice led to autoantibodies and insulitis.
Sequence
{Ser}{His}{Leu}{Val}{Glu}{Ala}{Leu}{Tyr}{Leu}{Val}{Cys}{Gly}
{Glu}{Arg}{Gly}
Sequence Shortening SHLVEALYLVCGERG
Molecular Formula C72H116N20O22S1
Molecular Weight 1645.9

Purity >95%
Gmp Flag 0
Storage Store at -20°C.
Note


Devendra D,Diabetes. 2005 Sep;54(9):2549-56.

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Cat. No. RP20391
Size
Price
1 mg $72.00