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Overlapping peptide library can be used in epitope mapping. The peptide library generation process is defined by two parameters, peptide length and offset number. The offset number reflects the degree of overlapping. Careful selections of these two parameters are important to achieve optimum balance between data value and the experiment cost. As a general guideline, shorter peptides are easier to synthesize but they have less chances for multiple epitope hits. Greater degree of overlapping (small offset number) gives more chances of multiple epitope hits. Both above stated cases increase the number of peptides to be synthesized for the peptide library. Read more »
T-cell truncated library:
T cell epitope identification is a critical part of designing highly specific immunotherapies. The T cell truncated library spans sequentially truncated sequences across a peptide sequence to identify important epitopes. Once identified, these sequences can be used to guide the development of targeted drugs or engineer specialized T cells for T cell therapy. Read more »
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