A New Vaccine for Acne Could Become A Reality Soon

New Vaccine for Acne Picture A new study published in Journal of Investigative Dermatology describes the possibility of a vaccine created against acne. Researchers have demonstrated for the first time that antibodies against a toxin that is secreted by bacteria during acne vulgaris can help reduce inflammation of acne lesions on the skin.

Acne is a persistent problem that affects hundreds of millions of adolescents and adults around the World. The current treatment options of available to treat acne are often not effective or tolerable for about 85% of people who suffer from acne. Some current medicines have also been known to cause terrible side effects such as skin dryness, irritation, to more severe ones such as depression, suicidal thoughts, and birth defects. An acne vaccine could be the key to circumventing these adverse side effects of individuals who suffer from acne.

This vaccine is the first of it’s kind to target a bacterial specimen that already lives within the human skin instead of a foreign invading pathogen. Researchers began by first demonstrating the toxin secreted from the Propionibacterium acnes (P. acnes), called Christie-Atkins-Munch-Peterson (CAMP) factor, is able to induce inflammatory responses. Investigators then explored if they could inhibit that inflammation by using antibodies to neutralize this factor in mice and ex vivo in human skin cells. Their results showed that the application of monoclonal antibodies to CAMP 2 factor was able to decrease the inflammatory response in both systems. The findings support P. acnes CAMP factor as a promising target for acne immunotherapy. This discovery is of particular importance because it is the first published observation of CAMP factor being implemented in the pathogenesis of acne vulgaris. In the future, this group hopes to focus on creating a non-toxic targeted vaccine against acne that will be safe for human application.

The Anti-Inflammatory Activities of Propionibacterium acnes CAMP Factor-Targeted Acne Vaccines (June 2018)

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