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Manual
COAs

DDB1-CRBN

The DDB1-CRBN complex is a crucial component of the E3 ubiquitin ligase system, specifically known as the DCX (DDB1-CUL4-X-box) E3 ubiquitin ligase complex, in which CRBN is the substrate recognition component. The complex tags specific proteins with ubiquitin molecules, signaling them for degradation. This process is essential for maintaining protein homeostasis within the cell.
$150.00
RP-D00001-20

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Description

The DDB1-CRBN complex is a crucial component of the E3 ubiquitin ligase system, specifically known as the DCX (DDB1-CUL4-X-box) E3 ubiquitin ligase complex, in which CRBN is the substrate recognition component. The complex tags specific proteins with ubiquitin molecules, signaling them for degradation. This process is essential for maintaining protein homeostasis within the cell. 
Product Introduction
Species Homo sapiens
Construct Full length
Appearance Clear liquid
Accession# Q16531, Q96SW2
Purity ≥ 90% by SDS-PAGE
Endotoxin Level ≤ 100 EU/mg
Source Insect cell Sf9
Theoretical Molecular Weight 127 kDa for DDB1, and 52 kDa for CRBN
Tag His tag at N-terminus of CRBN
Application Drug discovery of Targeted Protein Degradation (TPD) molecules, such as PROTACs and Molecular Glues. In vitro binding assay etc. 
Formulation Supplied as a solution of 50 mM Tris, 500 mM NaCl, 10% Glycerol, 2 mM TCEP, pH 7.5
Storage & Stability This product remains stable for up to 12 months at -80±5°C. Avoid repeated freeze-thaw cycles.
Note For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
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