Catalog Products » DNA damage-binding protein 1 - DDB1- and CUL4-associated factor 12
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DDB1-DCAF12

The DDB1-DCAF12 complex is part of the CUL4-RBX1-DDB1-DCAF12 (CRL4DCAF12) E3 ubiquitin ligase complex of the DesCEND (destruction via C-end degrons) pathway. DCAF12 is the substrate recognition component of the complex, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.
$150.00
RP-D00002-20

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Description

The DDB1-DCAF12 complex is part of the CUL4-RBX1-DDB1-DCAF12 (CRL4DCAF12) E3 ubiquitin ligase complex of the DesCEND (destruction via C-end degrons) pathway. DCAF12 is the substrate recognition component of the complex, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.
Product Introduction
Species Homo sapiens
Construct Full length
Appearance Clear liquid
Accession# Q16531, Q5T6F0
Purity ≥ 90% by SDS-PAGE
Endotoxin Level ≤ 100 EU/mg
Source Insect cell Sf9
Theoretical Molecular Weight 127 kDa for DDB1, and 52 kDa for DCAF12
Tag His tag at N-terminus of DCAF12
Application Drug discovery of Targeted Protein Degradation (TPD) molecules, such as PROTACs and Molecular Glues. In vitro binding assay etc.
Formulation Supplied as a solution of 50 mM Tris， 300 mM NaCl，10% Glycerol， 2 mM TCEP， pH 7.5
Storage & Stability This product remains stable for up to 12 months at -80±5°C. Avoid repeated freeze-thaw cycles.
Note For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
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DDB1-DCAF12

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