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POLQ

Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis. POLQ is often overexpressed in various cancers, especially those with HR deficiencies, such as BRCA1/2-mutated cancers.
$120.00
RP-D00004-20

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Description

Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis. POLQ is often overexpressed in various cancers, especially those with HR deficiencies, such as BRCA1/2-mutated cancers.
Background
Synonyms POLH
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Product Introduction
Species Homo sapiens
Construct Helicase domain, aa 1-894
Appearance Clear liquid
Accession# O75417
Purity ≥ 90% by SDS-PAGE
Endotoxin Level ≤ 100 EU/mg
Source Insect cell Sf9
Theoretical Molecular Weight 99 kDa
Tag His tag at the N-terminus
Application Drug discovery for cancer therapeutics. In vitro affinity assays, activity assays etc. 
Formulation Supplied as a solution of 50 mM Tris, 500 mM NaCl, 5% Glycerol, 2 mM TCEP, pH 8.0
Storage & Stability This product remains stable for up to 12 months at -80±5°C. Avoid repeated freeze-thaw cycles.
Note For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
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POLQ

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