Catalog Products » Bone Morphogenetic Protein-2 (BMP-2), Human

Bone Morphogenetic Protein-2 (BMP-2), Human

*This product has been discontinued!*
Human Bone Morphogenetic Protein-2 (BMP-2) is a bone-growth regulatory factor and a member of the transforming growth factor-β (TGF-β) superfamily of proteins. Human Bone Morphogenetic Protein-2 (BMP-2) is synthesized as large precursor molecules, which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or as a heterodimer of two related bone morphogenetic proteins. Recombinant human Bone Morphogenetic Protein-2 (BMP-2) produced in E. coli is a homodimeric, non-glycosylated polypeptide chain containing 115 amino acids and having a molecular mass of 26,018 Da. Human Bone Morphogenetic Protein-2 (BMP-2) is purified by proprietary chromatographic techniques.
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Product Introduction
Purity Greater than 95.0% as determined by the following methods:
(a) Analysis by SEC-HPLC
(b) Analysis by reducing and non-reducing SDS-PAGE silver-stained gel
Endotoxin Level Less than 0.1 ng/μg (1 IEU/μg) of Bone Morphogenetic Protein-2
Formulation The protein was lyophilized after extensive dialysis against 50mM Acetic acid.
Reconstitution It is recommended that the lyophilized rHuBMP-2 be reconstituted in sterile 20 mM HAc (acetic acid) not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.

Background
Target Background Human Bone Morphogenetic Protein-2 (BMP-2) is a bone-growth regulatory factor and a member of the transforming growth factor-β (TGF-β) superfamily of proteins. Human Bone Morphogenetic Protein-2 (BMP-2) is synthesized as large precursor molecules, which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or as a heterodimer of two related bone morphogenetic proteins.
Recombinant human Bone Morphogenetic Protein-2 (BMP-2) produced in E. coli is a homodimeric, non-glycosylated polypeptide chain containing 115 amino acids and having a molecular mass of 26,018 Da. Human Bone Morphogenetic Protein-2 (BMP-2) is purified by proprietary chromatographic techniques.
Synonyms rHuBMP-2; Bone Morphogenetic Protein2; BMP-2; BMP2

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