Catalog Products » Recombinant Proteins » Cytokines » IL-2, Human 
IL-2, Human 

Lane 1: 2 μg of IL-2, Human , non-reducing (NR)
Lane 2: 2 μg of IL-2, Human , reducing (R) )
> 95% as analyzed by SDS-PAGE

IL-2, Human 

Interleukin-2 (IL-2) is a Oglycosylated, four α-helix bundle cytokine that has potent stimulatory activity for antigen-activated T cells. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes.
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Product Introduction
Species Human
Protein Construction
IL-2 (Ala21-Thr153)
Accession # P60568
Purity > 95% as analyzed by SDS-PAGE
> 95% as analyzed by HPLC
Endotoxin Level < 1 EU/μg of protein by LAL method
Biological Activity The ED50 as determined by the dose-dependant stimulation of the proliferation of CTLL-2 was found to be < 0.1 ng/ml, corresponding to a specific activity of > 1.0 × 107 IU/mg.
Expression System E. coli
Theoretical Molecular Weight 15.3 kDa
N-terminal Sequence Analysis The sequence of the first five N-terminal amino acids wa determined and found to be Met-Ala-Pro-Thr-Ser-Ser.
Apparent Molecular Weight 15,300 Da
Formulation Lyophilized from a 0.2 μm filtered solution in 10 mM sodium citrate, pH 4.0.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile 18 MΩ-cm H₂O up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.

Examples
  • IL-2, Human 
  • IL-2, Human 

    Lane 1: 2 μg of IL-2, Human , non-reducing (NR)
    Lane 2: 2 μg of IL-2, Human , reducing (R) )
    > 95% as analyzed by SDS-PAGE


Background
Target Background Interleukin-2 (IL-2) is a Oglycosylated, four α-helix bundle cytokine that has potent stimulatory activity for antigen-activated T cells. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes.
Synonyms IL2; IL-2; TCGF; lymphokine; interleukin 2

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.


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