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CD40L/CD154/TRAP, Human

CD40 Ligand (CD40L/CD154/TRAP) is a membrane glycoprotein and differentiation antigen expressed on the surface of T-cells. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. It also costimulates proliferation of activated T-cell and this is accompanied by the production of IFN-γ, TNF-α, and IL2. CD40 ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes.
$75.00
Z02022-10

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Product Introduction
Species Human
Protein Construction
CD40L (Met113-Leu261)
Accession # P29965
Purity > 95% as analyzed by SDS-PAGE
Endotoxin Level < 1 EU/μg of protein by LAL method
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System E. coli
Theoretical Molecular Weight 16.3 kDa
N-terminal Sequence Analysis The sequence of the first five N-terminal amino acids was determined and found to be Met-Gln-Lys-Gly-Asp.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile 18 MΩ-cm H₂O up to 100 µg/ml.
Storage & Stability Upon receiving, this product remains stable for 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for 1 week at 4°C or for 3 months at -20°C. Avoid repeated freeze-thaw cycles.
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CD40L/CD154/TRAP, Human

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CD40L/CD154/TRAP, Human

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Background
Target Background CD40 Ligand (CD40L/CD154/TRAP) is a membrane glycoprotein and differentiation antigen expressed on the surface of T-cells. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. It also costimulates proliferation of activated T-cell and this is accompanied by the production of IFN-γ, TNF-α, and IL2. CD40 ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes.
Synonyms CD40 ligand; CD40-L; T-cell antigen Gp39; TNF-related activation protein; Tumor necrosis factor ligand superfamily member 5; CD_antigen: CD154; CD40LG; TNFSF5
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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.