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Catalog Products » Recombinant Proteins » Other Catalog Proteins » Angiostatin K1-3, Human

Angiostatin K1-3, Human

Synonyms Angiostatin K1-3, Human;
Description Angiostatin K1-3 is a ~30 kDa fragment of plasminogen that has been shown to act as a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo. Recombinant angiostatin is expressed in E. coli.
Species Human
Source E. coli
Biological Activity Fully biologically active when compared to standard. The specific activity determined by an assay on anti-proliferation and anti-migration using endothelial cells in vitro and anti-angiogenesis in vivo is 5.5 × 105 IU/mg.
Sequence
VYLSECKTGN GKNYRGTMSK TKNGITCQKW SSTSPHRPRF
SPATHPSEGL EENYCRNPDN DPQGPWCYTT DPEKRYDYCD
ILECEEECMH CSGENYDGKI SKTMSGLECQ AWDSQSPHAH
GYIPSKFPNK NLKKNYCRNP DRELRPWCFT TDPNKRWELC
DIPRCTTPPP SSGPTYQCLK GTGENYRGNV AVTVSGHTCQ
HWSAQTPHTH NRTPENFPCK NLDENYCRNP DGKRAPWCHT
TNSQVRWEYC KIPSCDSSP

Measured Molecular Weight Approximately 29.7 KDa, a single non-glycosylated polypeptide chain containing 259 amino acids.
Purity > 95 % by SDS-PAGE and HPLC analyses.
Formulation Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM NaAc, pH 5.5, 4 % mannitol.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Endotoxin Level Less than 1 EU/μg of rHuAngiostatin as determined by LAL method.
Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder.
Usage This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.




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Cat. No. Z02730
Size
Price
10 ug $59.00
50 ug $135.00