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Catalog Products » Recombinant Proteins » Cytokines » Brain Natriuretic Peptide (BNP), Human

BNP, Human

Description Natriuretic Peptide Precursor B acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body's salt and water balance. Improves heart function.
Species Human
Source E. coli

Measured Molecular Weight Approximately 3.5 kDa, a single non-glycosylated polypeptide chain containing 32 amino acids.
Purity > 97 % by SDS-PAGE and HPLC analyses.
Formulation Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Endotoxin Level Less than 1 EU/μg of rHuBNP as determined by LAL method.
Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder.
Usage This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.

Lu W, .et al Multiplex Detection Of B-Type Natriuretic Peptide, Cardiac Troponin I And C-Reactive Protein With Photonic Suspension Array. PLoS One.\x0a2012 7(7):e41448.\x0a

Moltzau LR., et al. Different compartmentation of responses to BNP and CNP in failing rat ventricle. J Pharmacol Exp Ther. 2014July

LR Moltzau., et al. Different Compartmentation of Responses to Brain Natriuretic Peptide and C-Type Natriuretic Peptide in Failing Rat Ventricle. J Pharmacol Exp Ther. 2014July;350(3):681-90

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Cat. No. Z02746
100 ug $159.00
1 mg $3600.00