Exendin-4

Exendin-4 is a novel 39-amino acid peptide isolated from the venom of the Gila monster Heloderma suspectum. It shares 53% sequence homology with GLP-17-36amide and interacts with the same membrane receptor. Exendin-4 enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying in vivo. It also promotes ÃŸ-cell proliferation and neogenesis in vitro and in animal models.

Price	$180.00
Cat. No.	Z02811-100
Size	100 μg 1 mg Buy in bulk
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Product Introduction Background Bottom Notes

Product Introduction

Species

Gila monster

Protein Construction

Exendin-4 (His48-Ser86)
Accession # P26349

Purity

> 96% as analyzed by SDS-PAGE
> 96% as analyzed by HPLC

Endotoxin Level

< 0.2 EU/μg of protein by LAL method

Expression System

E. coli

Theoretical Molecular Weight

4.2 kDa

Application

1. Regulates Glucose levels rapidly.
2. Reduces Insulin resistence.
3. Reduces Glucagon.
4. Reduces HbA1c.
5. Stimulates beta cell growth which stimulates insulin production.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4.

Reconstitution

It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.

Storage & Stability

Upon receiving, this product remains stable for 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for 1 week at 4°C or for 3 months at -20°C. Avoid repeated freeze-thaw cycles.

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Background

Target Background

Synonyms

Exendin-4

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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.