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Catalog Products » Recombinant Proteins » Growth Factors » Macrophage Colony Stimulating Factor (M-CSF), Human(CHO-expressed)

M-CSF, Human(CHO-expressed)

Synonyms CSF1, CSF-1, MCSF
Description Human Macrophage-Colony Stimulating Factor (M-CSF), also known as Colony Stimulating Factor-1 (CSF-1), can stimulate the survival, proliferation and differentiation of mononuclear phagocytes, in addition to the spreading and motility of macrophages. M-CSF is mainly produced by monocytes, macrophages, fibroblasts, and endothelial cells. M-CSF interaction with its receptor, c-fms, has been implicated in the growth, invasion, and metastasis of of several diseases, including breast and endometrial cancers.
Species Human
Source CHO
Biological Activity ED50< 5 ng/ml, measured in a cell proliferation assay using Murine M-NFS-60 cells, corresponding to a specific activity of > 2×105 units/mg.
Sequence
EEVSEYCSHM IGSGHLQSLQ RLIDSQMETS CQITFEFVDQ
EQLKDPVCYL KKAFLLVQDI MEDTMRFRDN TPNAIAIVQL
QELSLRLKSC FTKDYEEHDK ACVRTFYETP LQLLEKVKNV
FNETKNLLDK DWNIFSKNCN NSFAECSSQG HERQSEGS

Measured Molecular Weight 32-40 kDa, observed by non-reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level <0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human Macrophage-Colony Stimulating Factor (rhM-CSF) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhM-CSF should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only

  • M-CSF, Human(CHO-expressed)
  • M-CSF, Human(CHO-expressed)

    Biological Activity
    M-CSF, Human (Cat. No. Z02924) stimulates cell proliferation of M-NFS-60 cells. The ED50 for this effect is less than 5ng/mL.


1. Jani R. Jensen et al. (2010), Fertil Steril. 93(1): 251.

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Cat. No. Z02924
Size
Price
10 ug $85.00
50 ug $275.00
1 mg $2100.00