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Catalog Products » Recombinant Proteins » Hormones » Growth Hormone (GH), Human(CHO-expressed)

GH, Human(CHO-expressed)

Synonyms GH1, GH, GHN, GH-N, hGH-N,Pituitary growth hormone, Growth hormone 1, Somatotropin
Description Growth hormone (GH), also known as somatotropin, is a member of a family of growth factors that includes prolactin, placental lactogens, proliferins, and somatolactin. It is synthesized primarily by somatotropes in the anterior pituitary and is stored in secretary granules. The pulsatile release of GH into circulation is regulated by the concerted actions of the hypothalamic hormones-GH-releasing hormone (GHRH) and somatostatin (SST) - as well as by signals from the periphery - ghrelin and leptin. The human GH cDNA encodes a 217 amino acid (aa) residue precursor protein with a 26 aa putative signal peptide. By alternative splicing, at least four isoforms of GH have been identified.
Species Human
Source CHO
Biological Activity ED50 < 0.5 ng/ml, measured in a cell proliferation assay using Nb2-11 cells, corresponding to a specific activity of >2 x 106 units/mg
Sequence
FPTIPLSRLF DNASLRAHRL HQLAFDTYQE FEEAYIPKEQ
KYSFLQNPQT SLCFSESIPT PSNREETQQK SNLELLRISL
LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEG
IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY
GLLYCFRKDM DKVETFLRIV QCRSVEGSCG F

Measured Molecular Weight 20-24 kDa, observed by non-reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human Growth Hormone (GH) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhGH should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03005
Size
Price
10 ug $75.00
50 ug $325.00
1 mg $2200.00