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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-5 (IL-5), Human

IL-5, Human

Synonyms EDF, BCDFII, TRF
Description Interleukin-5 (IL-5), produced by mast cells, T cells and eosinophils, is responsible for the activities attributed to eosinophil differentiating factor, B cell growth factor II and T cell-replacing factor (TRF). It can increase production and mobilization of eosinophils and CD34+ progenitors from the bone marrow. IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. IL-5 also promotes differentiation of basophils and primes them for histamine and leukotriene release.
Recombinant Human Interleukin-5 (rhIL-5) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 116 amino acids each. A fully biologically active molecule, rhIL-5 has a molecular mass of 26.5 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Species Human
Source E. coli
Specific Activity ED50 < 1.0 ng/ml, measured by a cell proliferation assay using TF-1 Cells, corresponding to a specific activity of > 1.0× 106 units/mg.
Sequence
MIPTEIPTSA LVKETLALLS THRTLLIANE TLRIPVPVHK
NHQLCTEEIF QGIGTLESQT VQGGTVERLF KNLSLIKKYI
DGQKKKCGEE RRRVNQFLDY LQEFLGVMNT EWIIES

Measured Molecular Weight 26.5 kDa, observed by non-reducing SDS-PAGE.
Purity > 95% by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against 25mM Tris, pH8.0.
Reconstitution Reconstituted in ddH2O at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human Interleukin-5 (rhIL-5) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhIL-5 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only

  • IL-5, Human
  • IL-5, Human

    ED₅₀< 1.0 ng/ml, measured by a cell proliferation assay using TF-1 Cells, corresponding to a specific activity of > 1.0× 10⁶ units/mg.




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Cat. No. Z03007
Size
Price
50 ug $195.00
10 ug $85.00
1 mg $1500.00
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