• English
  • Sign In
  • Contact Us
×
Catalog Products » Recombinant Proteins » Other Catalog Proteins » Neuroserpin, Human

Neuroserpin, Human

Synonyms Serpin I1, Protease inhibitor 12
Description Neuroserpin is an inhibitory serpin that is expressed predominantly in central nervous system. Although the physiological target of neuroserpin is still unclear, cumulative evidence suggest that it plays an important role in controlling proteolytic degradation of extracellular matrix (ECM) during synaptogenesis and the subsequent development of neuronal plasticity. In the adult brain, neuroserpin is secreted from the growth cones of neurons in areas where synaptic changes are associated with learning and memory, i.e. cerebral cortex, hippocampus, and amygdala. The neuroprotective role of neuroserpin has been demonstrated in transgenic mice lacking neuroserpin expression. The deficiency of neuroserpin in these mice was associated with motor neuron disease characterized by axonal degradation. In humans, defects in neuroserpin, caused by point mutations in the neuroserpin gene, underlie a hereditary disorder called the familial encephalopathy with neuroserpin inclusion bodies (FENIB).
Species Human
Source CHO
Biological Activity ED50 < 2 µg/ml, measured by the dose-dependent stimulation of the proliferation of rat C6 cells, corresponding to a specific activity of > 500 units/mg.
Sequence
TGATFPEEAI ADLSVNMYNR LRATGEDENI LFSPLSIALA
MGMMELGAQG STQKEIRHSM GYDSLKNGEE FSFLKEFSNM
VTAKESQYVM KIANSLFVQN GFHVNEEFLQ MMKKYFNAAV
NHVDFSQNVA VANYINKWVE NNTNNLVKDL VSPRDFDAAT
YLALINAVYF KGNWKSQFRP ENTRTFSFTK DDESEVQIPM
MYQQGEFYYG EFSDGSNEAG GIYQVLEIPY EGDEISMMLV
LSRQEVPLAT LEPLVKAQLV EEWANSVKKQ KVEVYLPRFT
VEQEIDLKDV LKALGITEIF IKDANLTGLS DNKEIFLSKA
IHKSFLEVNE EGSEAAAVSG MIAISRMAVL YPQVIVDHPF
FFLIRNRRTG TILFMGRVMH PETMNTSGHD FEEL

Measured Molecular Weight 40-45 kDa, observed by non-reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human Neuroserpin remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rh_Neuroserpin should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




Notice there is no results found, you can visit "Citations Database" for other results.







For more documents, please visit "Technical Support".

Cat. No. Z03009
Size
Price
10 ug $59.00
50 ug $159.00
1 mg $1200.00