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Catalog Products » Recombinant Proteins » Growth Factors » Insulin-like growth factor I (IGF-I), Human

IGF-I, Human

IGF-I, Human

ED₅₀< 5 ng/ml, measured by a cell proliferation assay using FDC-P1 cells, corresponding to a specific activity of > 2.0× 10⁵ units/mg.

IGF-I, Human

GenScript product showed better activity compared to competitor S

Synonyms IGF-IA; Somatamedin C
Description Insulin-like growth factor I (IGF-I) also known as Somatamedin C is a hormone similar in molecular structure to insulin. Human IGF-I has two isoforms (IGF-IA and IGF-IB) which is differentially expressed by various tissues. Mature human IGF-I respectively shares 94% and 96% aa sequence identity with mouse and rat IGF-I. Both IGF-I and IGF-II (another ligand of IGF) can signal through the IGF-I receptor (IGFIR), but IGF-II can alone bind the IGF-II receptor (IGFIIR/ Mannose-6-phosphate receptor). IGF-I plays an important role in childhood growth and continues to have anabolic effects in adults.
Recombinant human Insulin-like growth factor I (rhIGF-I) produced in E. coli is a single non-glycosylated polypeptide chain containing 70 amino acids. A fully biologically active molecule, rhIGF-I has a molecular mass of 7.7 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Accession No P05019
Species Human
Source E. coli
Biological Activity ED50 < 5 ng/ml, measured by a cell proliferation assay using FDC-P1 cells, corresponding to a specific activity of > 2.0× 105 units/mg.
Sequence
GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ
TGIVDECCFR SCDLRRLEMY CAPLKPAKSA

Measured Molecular Weight 7.7 kDa, observed by reducing SDS-PAGE.
Purity > 95% by SDS-PAGE and HPLC analyses.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human Insulin-like growth factor I (rhIGF-I) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhIGF-I should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only

  • IGF-I, Human
  • IGF-I, Human

    ED₅₀< 5 ng/ml, measured by a cell proliferation assay using FDC-P1 cells, corresponding to a specific activity of > 2.0× 10⁵ units/mg.

  • IGF-I, Human
  • IGF-I, Human

    GenScript product showed better activity compared to competitor S


Cat. No.
Product Name
Price
Z03178-10
IGF-I, Mouse - 10 ug
$39.00
Z03146-10
IGF-I, Rat - 10 ug
$25.00
Z03298-10
IGF-I (N-Met), Human - 10 ug
$15.00
 


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Cat. No. Z03017
Size
Price
10 ug $39.00
50 ug $75.00
1 mg $125.00